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Nuclear pore complex tethers to the cytoskeleton

Goldberg, Martin W.

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Abstract

The nuclear envelope is tethered to the cytoskeleton. The best known attachments of all elements of the cytoskeleton are via the so-called LINC complex. However, the nuclear pore complexes, which mediate the transport of soluble and membrane bound molecules, are also linked to the microtubule network, primarily via motor proteins (dynein and kinesins) which are linked, most importantly, to the cytoplasmic filament protein of the nuclear pore complex, Nup358, by the adaptor BicD2. The evidence for such linkages and possible roles in nuclear migration, cell cycle control, nuclear transport and cell architecture are discussed.

Citation

Goldberg, M. W. (2017). Nuclear pore complex tethers to the cytoskeleton. Seminars in Cell and Developmental Biology, 68, 52-58. https://doi.org/10.1016/j.semcdb.2017.06.017

Journal Article Type Article
Acceptance Date Jun 23, 2017
Online Publication Date Jul 1, 2017
Publication Date Jul 1, 2017
Deposit Date Jul 24, 2017
Publicly Available Date Jul 1, 2018
Journal Seminars in Cell and Developmental Biology
Print ISSN 1084-9521
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 68
Pages 52-58
DOI https://doi.org/10.1016/j.semcdb.2017.06.017

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