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The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens

Djoko, Karrera Y.; Ong, Cheryl-lynn Y.; Walker, Mark J.; McEwan, Alastair G.

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Authors

Cheryl-lynn Y. Ong

Mark J. Walker

Alastair G. McEwan



Abstract

Zinc (Zn) and copper (Cu) are essential for optimal innate immune function, and nutritional deficiency in either metal leads to increased susceptibility to bacterial infection. Recently, the decreased survival of bacterial pathogens with impaired Cu and/or Zn detoxification systems in phagocytes and animal models of infection has been reported. Consequently, a model has emerged in which the host utilizes Cu and/or Zn intoxication to reduce the intracellular survival of pathogens. This review describes and assesses the potential role for Cu and Zn intoxication in innate immune function and their direct bactericidal function.

Citation

Djoko, K. Y., Ong, C. Y., Walker, M. J., & McEwan, A. G. (2015). The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens. Journal of Biological Chemistry, 290(31), 18954-18961. https://doi.org/10.1074/jbc.r115.647099

Journal Article Type Article
Online Publication Date Jun 8, 2015
Publication Date Jun 30, 2015
Deposit Date Sep 6, 2017
Publicly Available Date Oct 17, 2017
Journal Journal of Biological Chemistry
Print ISSN 0021-9258
Electronic ISSN 1083-351X
Publisher American Society for Biochemistry and Molecular Biology
Peer Reviewed Peer Reviewed
Volume 290
Issue 31
Pages 18954-18961
DOI https://doi.org/10.1074/jbc.r115.647099

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Copyright Statement
This research was originally published in Journal of Biological Chemistry. Karrera Y. Djoko, Cheryl-lynn Y. Ong, Mark J. Walker and Alastair G. McEwan. The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens. Journal of Biological Chemistry. 2015. 290: 18954-18961. © the American Society for Biochemistry and Molecular Biology







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