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Flow-Assisted Synthesis: A Key Fragment of SR 142948A

Kitching, Matthew O.; Dixon, Olivia E.; Baumann, Marcus; Baxendale, Ian R.

Flow-Assisted Synthesis: A Key Fragment of SR 142948A Thumbnail


Authors

Olivia E. Dixon

Marcus Baumann



Abstract

We report a series of multi-step flow operations to deliver an advanced hydrazine intermediate used in the assembly of the neurotensin modulator SR 142948A. Several new reactor configurations have enabled chemical transformations that would be otherwise difficult or dangerous to perform at scale. Overall the flow approach has allowed the preparation of kilogram quantities of the required hydrazine through a short and efficient route.

Journal Article Type Article
Acceptance Date Jun 24, 2017
Online Publication Date Sep 8, 2017
Publication Date Dec 1, 2017
Deposit Date Sep 18, 2017
Publicly Available Date Sep 8, 2018
Journal European Journal of Organic Chemistry
Print ISSN 1434-193X
Electronic ISSN 1099-0690
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 2017
Issue 44
Pages 6540-6553
DOI https://doi.org/10.1002/ejoc.201700904
Public URL https://durham-repository.worktribe.com/output/1376220

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Copyright Statement
This is the peer reviewed version of the following article: Kitching, M. O., Dixon, O. E., Baumann, M. and Baxendale, I. R. (2017), Flow-Assisted Synthesis: A Key Fragment of SR 142948A. European Journal of Organic Chemistry, 2017(44): 6540-6553, which has been published in final form at https://doi.org/10.1002/ejoc.201700904. This article may be used for non-commercial purposes in accordance With Wiley-VCH Terms and Conditions for self-archiving.






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