Brian Gregoire
Peptide Formation on Layered Mineral Surfaces: The Key Role of Brucite-like Minerals on the Enhanced Formation of Alanine Dipeptides
Gregoire, Brian; Greenwell, Hugh Christopher; Fraser, Donald G.
Abstract
Alkaline hydrothermal vent environments have gained much attention as potential sites for abiotic synthesis of a range of organic molecules. However the key process of peptide formation has generally been undertaken at lower pH, and using dissolved copper ions to enhance selectivity and reactivity. Here, we explore whether layered precipitate minerals, abundant at alkaline hydrothermal systems, can promote peptide bond formation for surface-bound alanine under cycles of wetting and drying. While we find low level activity in brucite and binary layered double hydroxide carbonate minerals (typically < 0.1% yield), the inclusion of structural copper to form a ternary layered double hydroxide mineral significantly increased the yield to > 7 %. However the performance decreased over successive wetting/drying cycles. Control experiments show that this high degree of dipeptide formation cannot be attributed to leached copper from the mineral structure. While only dipeptides are observed, the yields obtained suggest that such processes, if occurring on the early Earth, could have added to the pool of available biological building units.
Citation
Gregoire, B., Greenwell, H. C., & Fraser, D. G. (2018). Peptide Formation on Layered Mineral Surfaces: The Key Role of Brucite-like Minerals on the Enhanced Formation of Alanine Dipeptides. ACS Earth and Space Chemistry, 2(8), 852-862. https://doi.org/10.1021/acsearthspacechem.8b00052
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 22, 2018 |
Online Publication Date | Jul 3, 2018 |
Publication Date | Aug 16, 2018 |
Deposit Date | Jul 8, 2018 |
Publicly Available Date | Jul 3, 2019 |
Journal | ACS Earth and Space Chemistry |
Electronic ISSN | 2472-3452 |
Publisher | American Chemical Society |
Peer Reviewed | Peer Reviewed |
Volume | 2 |
Issue | 8 |
Pages | 852-862 |
DOI | https://doi.org/10.1021/acsearthspacechem.8b00052 |
Public URL | https://durham-repository.worktribe.com/output/1354837 |
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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS earth and space chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
https://doi.org/10.1021/acsearthspacechem.8b00052
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