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Endoplasmic Reticulum redox pathways: in sickness and in health

Benham, Adam M.

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Authors



Abstract

The Endoplasmic Reticulum (ER) is the major site for secretory protein production in eukaryotic cells and like an efficient factory, it has the capacity to expand or contract its output depending on the demand for its services. A primary function of the ER is to co‐ordinate the quality control of proteins as they enter this folding factory at the base of the secretory pathway. Reduction‐oxidation (redox) reactions have an important role to play in the quality control process, through the provision of disulfide bonds and by maintaining a favourable redox environment for oxidative protein folding. The ER is also a major contributor to calcium homeostasis and is a key site for lipid biosynthesis, two processes that additionally impact upon, and are influenced by, redox in the ER compartment.

Citation

Benham, A. M. (2019). Endoplasmic Reticulum redox pathways: in sickness and in health. The FEBS Journal, 286(2), 311--321. https://doi.org/10.1111/febs.14618

Journal Article Type Article
Acceptance Date Jul 27, 2018
Online Publication Date Aug 13, 2018
Publication Date Jan 31, 2019
Deposit Date Jul 31, 2018
Publicly Available Date Aug 13, 2019
Journal FEBS Journal
Print ISSN 1742-464X
Electronic ISSN 1742-4658
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 286
Issue 2
Pages 311--321
DOI https://doi.org/10.1111/febs.14618

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Copyright Statement
This is the accepted version of the following article: Benham, Adam M. (2019). Endoplasmic Reticulum redox pathways: in sickness and in health. The FEBS Journal 286(221): 311-321, which has been published in final form at https://doi.org/10.1111/febs.14618. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.







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