Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents

Marsh, James W.; Djoko, Karrera Y.; McEwan, Alastair G.; Huston, Wilhelmina M.

Abstract

Lipophilic copper (Cu)-containing complexes have shown promising antibacterial activity against a range of bacterial pathogens. To examine the susceptibility of the intracellular human pathogen Chlamydia trachomatis to copper complexes containing bis(thiosemicarbazone) ligands [Cu(btsc)], we tested the in vitro effect of CuII-diacetyl- and CuII-glyoxal-bis[N(4)-methylthiosemicarbazonato] (Cu(atsm) and Cu(gtsm), respectively) on C. trachomatis. Cu(atsm) and to a greater extent, Cu(gtsm), prevented the formation of infectious chlamydial progeny. Impacts on host cell viability and respiration were also observed in addition to the Chlamydia impacts. This work suggests that copper-based complexes may represent a new lead approach for future development of new therapeutics against chlamydial infections, although host cell impacts need to be fully explored.

Citation

Marsh, J. W., Djoko, K. Y., McEwan, A. G., & Huston, W. M. (2017). Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents. Pathogens and Disease, 75(7), Article ftx084. https://doi.org/10.1093/femspd/ftx084

• Journal Article Type: Article
• Acceptance Date: Jul 20, 2017
• Online Publication Date: Jul 24, 2017
• Publication Date: Sep 29, 2017
• Deposit Date: Sep 6, 2017
• Publicly Available Date: Jul 24, 2018
• Journal: Pathogens and Disease
• Electronic ISSN: 2049-632X
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 75
• Issue: 7
• Article Number: ftx084
• DOI: https://doi.org/10.1093/femspd/ftx084
• Public URL: https://durham-repository.worktribe.com/output/1350341