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Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents

Marsh, James W.; Djoko, Karrera Y.; McEwan, Alastair G.; Huston, Wilhelmina M.

Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents Thumbnail


Authors

James W. Marsh

Alastair G. McEwan

Wilhelmina M. Huston



Abstract

Lipophilic copper (Cu)-containing complexes have shown promising antibacterial activity against a range of bacterial pathogens. To examine the susceptibility of the intracellular human pathogen Chlamydia trachomatis to copper complexes containing bis(thiosemicarbazone) ligands [Cu(btsc)], we tested the in vitro effect of CuII-diacetyl- and CuII-glyoxal-bis[N(4)-methylthiosemicarbazonato] (Cu(atsm) and Cu(gtsm), respectively) on C. trachomatis. Cu(atsm) and to a greater extent, Cu(gtsm), prevented the formation of infectious chlamydial progeny. Impacts on host cell viability and respiration were also observed in addition to the Chlamydia impacts. This work suggests that copper-based complexes may represent a new lead approach for future development of new therapeutics against chlamydial infections, although host cell impacts need to be fully explored.

Citation

Marsh, J. W., Djoko, K. Y., McEwan, A. G., & Huston, W. M. (2017). Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents. Pathogens and Disease, 75(7), Article ftx084. https://doi.org/10.1093/femspd/ftx084

Journal Article Type Article
Acceptance Date Jul 20, 2017
Online Publication Date Jul 24, 2017
Publication Date Sep 29, 2017
Deposit Date Sep 6, 2017
Publicly Available Date Jul 24, 2018
Journal Pathogens and Disease
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 75
Issue 7
Article Number ftx084
DOI https://doi.org/10.1093/femspd/ftx084

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Copyright Statement
This is a pre-copyedited, author-produced version of an article accepted for publication in Pathogens and Disease following peer review. The version of record James W. Marsh, Karrera Y. Djoko, Alastair G. McEwan, Wilhelmina M. Huston (2017) Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents, Pathogens and Disease, 75(7), ftx084 is available online at: https://doi.org/10.1093/femspd/ftx084.







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