James W. Marsh
Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents
Marsh, James W.; Djoko, Karrera Y.; McEwan, Alastair G.; Huston, Wilhelmina M.
Authors
Dr Karrera Djoko karrera.djoko@durham.ac.uk
Associate Professor
Alastair G. McEwan
Wilhelmina M. Huston
Abstract
Lipophilic copper (Cu)-containing complexes have shown promising antibacterial activity against a range of bacterial pathogens. To examine the susceptibility of the intracellular human pathogen Chlamydia trachomatis to copper complexes containing bis(thiosemicarbazone) ligands [Cu(btsc)], we tested the in vitro effect of CuII-diacetyl- and CuII-glyoxal-bis[N(4)-methylthiosemicarbazonato] (Cu(atsm) and Cu(gtsm), respectively) on C. trachomatis. Cu(atsm) and to a greater extent, Cu(gtsm), prevented the formation of infectious chlamydial progeny. Impacts on host cell viability and respiration were also observed in addition to the Chlamydia impacts. This work suggests that copper-based complexes may represent a new lead approach for future development of new therapeutics against chlamydial infections, although host cell impacts need to be fully explored.
Citation
Marsh, J. W., Djoko, K. Y., McEwan, A. G., & Huston, W. M. (2017). Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents. Pathogens and Disease, 75(7), Article ftx084. https://doi.org/10.1093/femspd/ftx084
Journal Article Type | Article |
---|---|
Acceptance Date | Jul 20, 2017 |
Online Publication Date | Jul 24, 2017 |
Publication Date | Sep 29, 2017 |
Deposit Date | Sep 6, 2017 |
Publicly Available Date | Jul 24, 2018 |
Journal | Pathogens and Disease |
Electronic ISSN | 2049-632X |
Publisher | Oxford University Press |
Peer Reviewed | Peer Reviewed |
Volume | 75 |
Issue | 7 |
Article Number | ftx084 |
DOI | https://doi.org/10.1093/femspd/ftx084 |
Public URL | https://durham-repository.worktribe.com/output/1350341 |
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Copyright Statement
This is a pre-copyedited, author-produced version of an article accepted for publication in Pathogens and Disease following peer review. The version of record James W. Marsh, Karrera Y. Djoko, Alastair G. McEwan, Wilhelmina M. Huston (2017) Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents, Pathogens and Disease, 75(7), ftx084 is available online at: https://doi.org/10.1093/femspd/ftx084.
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