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Auditory Hallucinations and the Brain’s Resting-State Networks: Findings and Methodological Observations

Alderson-Day, Ben; Diederen, Kelly; Fernyhough, Charles; Ford, Judith M.; Horga, Guillermo; Margulies, Daniel S.; McCarthy-Jones, Simon; Northoff, Georg; Shine, James M.; Turner, Jessica; van de Ven, Vincent; van Lutterveld, Remko; Waters, Flavie; Jardri, Renaud

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Kelly Diederen

Judith M. Ford

Guillermo Horga

Daniel S. Margulies

Simon McCarthy-Jones

Georg Northoff

James M. Shine

Jessica Turner

Vincent van de Ven

Remko van Lutterveld

Flavie Waters

Renaud Jardri


In recent years, there has been increasing interest in the potential for alterations to the brain’s resting-state networks (RSNs) to explain various kinds of psychopathology. RSNs provide an intriguing new explanatory framework for hallucinations, which can occur in different modalities and population groups, but which remain poorly understood. This collaboration from the International Consortium on Hallucination Research (ICHR) reports on the evidence linking resting-state alterations to auditory hallucinations (AH) and provides a critical appraisal of the methodological approaches used in this area. In the report, we describe findings from resting connectivity fMRI in AH (in schizophrenia and nonclinical individuals) and compare them with findings from neurophysiological research, structural MRI, and research on visual hallucinations (VH). In AH, various studies show resting connectivity differences in left-hemisphere auditory and language regions, as well as atypical interaction of the default mode network and RSNs linked to cognitive control and salience. As the latter are also evident in studies of VH, this points to a domain-general mechanism for hallucinations alongside modality-specific changes to RSNs in different sensory regions. However, we also observed high methodological heterogeneity in the current literature, affecting the ability to make clear comparisons between studies. To address this, we provide some methodological recommendations and options for future research on the resting state and hallucinations.


Alderson-Day, B., Diederen, K., Fernyhough, C., Ford, J. M., Horga, G., Margulies, D. S., …Jardri, R. (2016). Auditory Hallucinations and the Brain’s Resting-State Networks: Findings and Methodological Observations. Schizophrenia Bulletin: The Journal of Psychoses and Related Disorders, 42(5), 1110-1123.

Journal Article Type Article
Online Publication Date Jun 8, 2016
Publication Date Sep 1, 2016
Deposit Date Sep 4, 2017
Publicly Available Date Oct 24, 2017
Journal Schizophrenia Bulletin
Print ISSN 0586-7614
Electronic ISSN 1745-1701
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 42
Issue 5
Pages 1110-1123


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Copyright Statement
© The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (,
which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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