Negishi cross-couplings in the synthesis of amino acids

Brittain, WDG; Cobb, SL

Abstract

The Negishi cross-coupling is a powerful C–C bond-forming reaction widely utilised in many areas of organic synthesis. This review details the use of Negishi cross-couplings in the synthesis of unnatural amino acids. The application of this reaction in the preparation of aromatic, heteroaromatic, and, complex amino acid derivatives are reviewed and presented herein.

Citation

Brittain, W., & Cobb, S. (2018). Negishi cross-couplings in the synthesis of amino acids. Organic and Biomolecular Chemistry, 16(1), 10-20. https://doi.org/10.1039/c7ob02682j

• Journal Article Type: Article
• Acceptance Date: Nov 27, 2017
• Online Publication Date: Nov 27, 2017
• Publication Date: Jan 7, 2018
• Deposit Date: Nov 6, 2017
• Publicly Available Date: Jan 4, 2018
• Journal: Organic and Biomolecular Chemistry
• Print ISSN: 1477-0520
• Electronic ISSN: 1477-0539
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 16
• Issue: 1
• Pages: 10-20
• DOI: https://doi.org/10.1039/c7ob02682j
• Public URL: https://durham-repository.worktribe.com/output/1344827