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Small-Molecule Povidone Analogs in Coamorphous Pharmaceutical Phases

Goodwin, Melissa; Musa, Osama; Berry, David; Steed, Jonathan W.

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Melissa Goodwin

Osama Musa

David Berry


The crystallization inhibitor polyvinylpyrrolidone (PVP) is commonly used as a stabilizer in the formation of amorphous polymer dispersions of poorly soluble pharmaceuticals. In this work we examine the use of a range of PVP-inspired small-molecule bis(lactams) as coformers in the stabilization of amorphous pharmaceutical phases creating coamorphous materials. The dimer of N-vinyl(caprolactam) (bisVCap, 3) was found to be an effective coamorphous-former at relatively low loading for carisoprodol, carbamazepine, isoniazid, and 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile (ROY).


Goodwin, M., Musa, O., Berry, D., & Steed, J. W. (2018). Small-Molecule Povidone Analogs in Coamorphous Pharmaceutical Phases. Crystal Growth and Design, 18(2), 701-709.

Journal Article Type Article
Acceptance Date Dec 18, 2017
Online Publication Date Jan 4, 2018
Publication Date Feb 7, 2018
Deposit Date Jan 5, 2018
Publicly Available Date Jan 4, 2019
Journal Crystal Growth and Design
Print ISSN 1528-7483
Electronic ISSN 1528-7505
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 18
Issue 2
Pages 701-709


Accepted Journal Article (2.3 Mb)

Copyright Statement
This document is the Accepted Manuscript version of a Published Work that will appear in final form in Crystal growth & design, copyright © American Chemical Society after peer review and technical editing by the publisher.

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