Analysis of air-, moisture- and solvent-sensitive chemical compounds by mass spectrometry using an inert atmospheric pressure solids analysis probe

Mosely, Jackie A; Stokes, Peter; Parker, David; Dyer, Philip W; Messinis, Antonis M

Abstract

A novel method has been developed that enables chemical compounds to be transferred from an inert atmosphere glove box and into the atmospheric pressure ion source of a mass spectrometer whilst retaining a controlled chemical environment. This innovative method is simple and cheap to implement on some commercially available mass spectrometers. We have termed this approach inert atmospheric pressure solids analysis probe (iASAP) and demonstrate the benefit of this methodology for two air-/moisture-sensitive chemical compounds whose characterisation by mass spectrometry is now possible and easily achieved. The simplicity of the design means that moving between iASAP and standard ASAP is straightforward and quick, providing a highly flexible platform with rapid sample turnaround.

Citation

Mosely, J. A., Stokes, P., Parker, D., Dyer, P. W., & Messinis, A. M. (2017). Analysis of air-, moisture- and solvent-sensitive chemical compounds by mass spectrometry using an inert atmospheric pressure solids analysis probe. European Journal of Mass Spectrometry, 24(1), 74-80. https://doi.org/10.1177/1469066717732286

• Journal Article Type: Article
• Acceptance Date: Aug 25, 2017
• Online Publication Date: Sep 19, 2017
• Publication Date: Sep 19, 2017
• Deposit Date: Apr 11, 2018
• Publicly Available Date: Apr 11, 2018
• Journal: European Journal of Mass Spectrometry
• Print ISSN: 1469-0667
• Electronic ISSN: 1751-6838
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• Volume: 24
• Issue: 1
• Pages: 74-80
• DOI: https://doi.org/10.1177/1469066717732286
• Public URL: https://durham-repository.worktribe.com/output/1329351