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Crystallographic texture and mineral concentration quantification of developing and mature human incisal enamel

Al-Mosawi, Mohammed; Davis, Graham Roy; Bushby, Andy; Montgomery, Janet; Beaumont, Julia; Al-Jawad, Maisoon

Crystallographic texture and mineral concentration quantification of developing and mature human incisal enamel Thumbnail


Authors

Mohammed Al-Mosawi

Graham Roy Davis

Andy Bushby

Julia Beaumont

Maisoon Al-Jawad



Abstract

For human dental enamel, what is the precise mineralization progression spatially and the precise timing of mineralization? This is an important question in the fundamental understanding of matrix-mediated biomineralization events, but in particular because we can use our understanding of this natural tissue growth in humans to develop biomimetic approaches to repair and replace lost enamel tissue. It is important to understand human tissues in particular since different species have quite distinct spatial and temporal progression of mineralization. In this study, five human central incisors at different stages of enamel maturation/mineralization were spatially mapped using synchrotron X-ray diffraction and X-ray microtomography techniques. From the earliest developmental stage, two crystallite-orientation populations coexist with angular separations between the crystallite populations of approximately 40° varying as a function of position within the tooth crown. In general, one population had significantly lower texture magnitude and contributed a higher percentage to the overall crystalline structure, compared to the other population which contributed only 20–30% but had significantly higher texture magnitude. This quantitative analysis allows us to understand the complex and co-operative structure-function relationship between two populations of crystallites within human enamel. There was an increase in the mineral concentration from the enamel-dentin junction peripherally and from the incisal tip cervically as a function of maturation time. Quantitative backscattered-electron analyses showed that mineralization of prism cores precedes that of prism boundaries. These results provide new insights into the precise understanding of the natural growth of human enamel.

Journal Article Type Article
Acceptance Date Aug 30, 2018
Online Publication Date Sep 27, 2018
Publication Date Sep 27, 2018
Deposit Date Sep 4, 2018
Publicly Available Date Sep 27, 2018
Journal Scientific Reports
Publisher Nature Research
Peer Reviewed Peer Reviewed
Volume 8
Article Number 14449
DOI https://doi.org/10.1038/s41598-018-32425-y
Public URL https://durham-repository.worktribe.com/output/1315823

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http://creativecommons.org/licenses/by/4.0/

Copyright Statement
© The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International
License, which permits use, sharing, adaptation, distribution and reproduction in any medium or
format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative
Commons license, and indicate if changes were made. Te images or other third party material in this
article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the
material. If material is not included in the article’s Creative Commons license and your intended use is not permitted
by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the
copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.





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