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Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals

Doupé, D.P.; Marshall, O.J; Dayton, H.; Brand, A.H.; Perrimon, N.

Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals Thumbnail


Authors

O.J Marshall

H. Dayton

A.H. Brand

N. Perrimon



Abstract

Epithelial homeostasis requires the precise balance of epithelial stem/progenitor proliferation and differentiation. While many signaling pathways that regulate epithelial stem cells have been identified, it is probable that other regulators remain unidentified. Here, we use gene-expression profiling by targeted DamID to identify the stem/progenitor-specific transcription and signaling factors in the Drosophila midgut. Many signaling pathway components, including ligands of most major pathways, exhibit stem/progenitor-specific expression and have regulatory regions bound by both intrinsic and extrinsic transcription factors. In addition to previously identified stem/progenitor-derived ligands, we show that both the insulin-like factor Ilp6 and TNF ligand eiger are specifically expressed in the stem/progenitors and regulate normal tissue homeostasis. We propose that intestinal stem cells not only integrate multiple signals but also contribute to and regulate the homeostatic signaling microenvironmental niche through the expression of autocrine and paracrine factors.

Citation

Doupé, D., Marshall, O., Dayton, H., Brand, A., & Perrimon, N. (2018). Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals. Proceedings of the National Academy of Sciences, 115(48), 12218-12223. https://doi.org/10.1073/pnas.1719169115

Journal Article Type Article
Acceptance Date Oct 11, 2018
Online Publication Date Nov 7, 2018
Publication Date Nov 7, 2018
Deposit Date Nov 6, 2018
Publicly Available Date Nov 8, 2018
Journal Proceedings of the National Academy of Sciences
Print ISSN 0027-8424
Electronic ISSN 1091-6490
Publisher National Academy of Sciences
Peer Reviewed Peer Reviewed
Volume 115
Issue 48
Pages 12218-12223
DOI https://doi.org/10.1073/pnas.1719169115
Public URL https://durham-repository.worktribe.com/output/1314037

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Published Journal Article (Advance online version) (1.5 Mb)
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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
Advance online version Copyright © 2018 the Author(s). This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).





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