Tom McLeish
The ‘allosteron’ model for entropic allostery of self-assembly
McLeish, Tom; Schaefer, C.; von der Heydt, A.C.
Authors
C. Schaefer
A.C. von der Heydt
Abstract
Using the simple ‘allosteron’ model, we show that it is possible, in principle, to elicit pathways by which fluctuation allostery affects self-assembly of protein complexes. We treat the cases of (i) protein fibrils and nucleation, (ii) n-mer protein complexes, and (iii) weakly attractive allosteric interactions in protein-like soft nanoscale objects that can be tuned to define exclusive self-associating families. This article is part of a discussion meeting issue ‘Allostery and molecular machines’.
Citation
McLeish, T., Schaefer, C., & von der Heydt, A. (2018). The ‘allosteron’ model for entropic allostery of self-assembly. Philosophical Transactions of the Royal Society B: Biological Sciences, 373(1749), Article 20170186. https://doi.org/10.1098/rstb.2017.0186
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 15, 2018 |
Online Publication Date | May 7, 2018 |
Publication Date | May 7, 2018 |
Deposit Date | Mar 20, 2019 |
Publicly Available Date | Mar 20, 2019 |
Journal | Philosophical Transactions of the Royal Society B: Biological Sciences |
Print ISSN | 0962-8436 |
Electronic ISSN | 1471-2970 |
Publisher | The Royal Society |
Peer Reviewed | Peer Reviewed |
Volume | 373 |
Issue | 1749 |
Article Number | 20170186 |
DOI | https://doi.org/10.1098/rstb.2017.0186 |
Public URL | https://durham-repository.worktribe.com/output/1305688 |
Related Public URLs | http://eprints.whiterose.ac.uk/143107/ |
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