The ‘allosteron’ model for entropic allostery of self-assembly

McLeish, Tom; Schaefer, C.; von der Heydt, A.C.

Abstract

Using the simple ‘allosteron’ model, we show that it is possible, in principle, to elicit pathways by which fluctuation allostery affects self-assembly of protein complexes. We treat the cases of (i) protein fibrils and nucleation, (ii) n-mer protein complexes, and (iii) weakly attractive allosteric interactions in protein-like soft nanoscale objects that can be tuned to define exclusive self-associating families. This article is part of a discussion meeting issue ‘Allostery and molecular machines’.

• Journal Article Type: Article
• Acceptance Date: Feb 15, 2018
• Online Publication Date: May 7, 2018
• Publication Date: May 7, 2018
• Deposit Date: Mar 20, 2019
• Publicly Available Date: Mar 20, 2019
• Journal: Philosophical Transactions of the Royal Society B: Biological Sciences
• Print ISSN: 0962-8436
• Electronic ISSN: 1471-2970
• Publisher: The Royal Society
• Peer Reviewed: Peer Reviewed
• Volume: 373
• Issue: 1749
• Article Number: 20170186
• DOI: https://doi.org/10.1098/rstb.2017.0186
• Public URL: https://durham-repository.worktribe.com/output/1305688
• Related Public URLs: http://eprints.whiterose.ac.uk/143107/