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Histamine and Delirium: Current Opinion

Chazot, Paul L.; Johnston, Laura; Mcauley, Edel; Bonner, Stephen

Histamine and Delirium: Current Opinion Thumbnail


Authors

Laura Johnston

Edel Mcauley

Stephen Bonner



Abstract

Delirium is a very common, but refractory clinical state, notably present in intensive care and in the growing aging community. It is characterized by fluctuating disturbances in a number of key behavioral features, namely cognition, mood, attention, arousal, and self-awareness. Histamine is arguably the most pleotropic neurotransmitter in the human brain, and this review provides a rationale, and proposes that this neuroactive amine plays a role in modulating the characteristic features of delirium. While centrally permeable H1 and H2 histamine receptor antagonists have pro-delirium potential, we propose that centrally permeable H3 histamine receptor antagonists may provide an exciting new strategy to combat delirium. The Histamine H4 receptor may also have an indirect inflammatory neuroglial role which requires further exploration.

Citation

Chazot, P. L., Johnston, L., Mcauley, E., & Bonner, S. (2019). Histamine and Delirium: Current Opinion. Frontiers in Pharmacology, 10, Article 299. https://doi.org/10.3389/fphar.2019.00299

Journal Article Type Article
Acceptance Date Mar 11, 2019
Online Publication Date Apr 9, 2019
Publication Date Apr 9, 2019
Deposit Date Apr 18, 2019
Publicly Available Date Apr 18, 2019
Journal Frontiers in Pharmacology
Electronic ISSN 1663-9812
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 10
Article Number 299
DOI https://doi.org/10.3389/fphar.2019.00299
Public URL https://durham-repository.worktribe.com/output/1303536

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
Copyright © 2019 Chazot, Johnston, Mcauley and Bonner. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.






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