C-H activation/metalation approaches for the synthesis of indolizine derivatives

Clososki, Giuliano Cesar; Steel, Patrick G.; Bertallo, Camila Rodrigues de Souza; Arroio, Thaís Rodrigues Arroio Rodrigues; Vessecchi, Ricardo; Toledo, Monica F.Z.J.; Sadler, Scott

Abstract

The C‐H borylation of indolizines has not previously been reported and in this communication, we describe our preliminary efforts to apply this chemistry to this scaffold and contrast this approach to directed metalation. Through these methodologies were possible obtain a library of substituted indolizines functionalized in both pyridinic and pyrrole ring.

Citation

Clososki, G. C., Steel, P. G., Bertallo, C. R. D. S., Arroio, T. R. A. R., Vessecchi, R., Toledo, M. F., & Sadler, S. (2019). C-H activation/metalation approaches for the synthesis of indolizine derivatives. European Journal of Organic Chemistry, 31-32, 5205-5213. https://doi.org/10.1002/ejoc.201900608

• Journal Article Type: Article
• Acceptance Date: Jun 5, 2019
• Publication Date: Sep 30, 2019
• Deposit Date: Jun 6, 2019
• Publicly Available Date: Jun 25, 2020
• Journal: European Journal of Organic Chemistry
• Print ISSN: 1434-193X
• Electronic ISSN: 1099-0690
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 31-32
• Pages: 5205-5213
• DOI: https://doi.org/10.1002/ejoc.201900608
• Public URL: https://durham-repository.worktribe.com/output/1300433