Claudia Dragonetti
A highly luminescent tetrahydrocurcumin Ir(III) complex with remarkable photoactivated anticancer activity
Dragonetti, Claudia; Colombo, Alessia; Fontani, Mattia; Roberto, Dominique; Williams, Gareth; Scotto di Perrotolo, Rossella; Casagrande, Francesca; Barozzi, Sara; Polo, Simona
Authors
Alessia Colombo
Mattia Fontani
Dominique Roberto
Professor Gareth Williams j.a.g.williams@durham.ac.uk
Professor
Rossella Scotto di Perrotolo
Francesca Casagrande
Sara Barozzi
Simona Polo
Abstract
Curcumin has chemopreventive properties against a variety of tumours, but it has poor bioavailability. Two new bis‐cyclometallated iridium(III) complexes have been prepared, featuring the natural product curcumin (CUR) or its reduced form, tetrahydrocurcumin (THC), as bidentate, anionic O^O‐binding ligands. The iridium THC complex is highly luminescent in deoxygenated solution and efficiently generates singlet oxygen under aerated conditions, whereas in the curcumin analogue, other non‐radiative decay pathways are competitive. The complexes are rapidly taken up into a variety of human tumour cell lines from solutions of micromolar concentration. They have negligible cytotoxicity in the absence of irradiation. When briefly irradiated by visible light, Ir‐THC becomes highly phototoxic, inducing rapid apoptosis within 2 h. The results show the high potential of such complexes as sensitizers in photodynamic therapy (PDT).
Citation
Dragonetti, C., Colombo, A., Fontani, M., Roberto, D., Williams, G., Scotto di Perrotolo, R., Casagrande, F., Barozzi, S., & Polo, S. (2019). A highly luminescent tetrahydrocurcumin Ir(III) complex with remarkable photoactivated anticancer activity. Chemistry - A European Journal, 25(33), 7948-7952. https://doi.org/10.1002/chem.201901527
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Apr 15, 2019 |
| Online Publication Date | May 13, 2019 |
| Publication Date | Jun 12, 2019 |
| Deposit Date | Apr 16, 2019 |
| Publicly Available Date | May 13, 2020 |
| Journal | Chemistry - A European Journal |
| Print ISSN | 0947-6539 |
| Electronic ISSN | 1521-3765 |
| Publisher | Wiley |
| Peer Reviewed | Peer Reviewed |
| Volume | 25 |
| Issue | 33 |
| Pages | 7948-7952 |
| DOI | https://doi.org/10.1002/chem.201901527 |
| Public URL | https://durham-repository.worktribe.com/output/1298592 |
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Copyright Statement
This is the accepted version of the following article: Dragonetti, Claudia, Colombo, Alessia, Fontani, Mattia, Roberto, Dominique, Williams, Gareth, Scotto di Perrotolo, Rossella, Casagrande, Francesca, Barozzi, Sara & Polo, Simona (2019). A highly luminescent tetrahydrocurcumin Ir(III) complex with remarkable photoactivated anticancer activity. Chemistry – A European Journal 25(33): 7948-7952 which has been published in final form at https://doi.org/10.1002/chem.201901527. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.