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Photochemical flow synthesis of 3‐hydroxyazetidines

Ruggeri, Michele; Dombrowski, Amanda Worthy; Djuric, Stevan W.; Baxendale, Ian Richard


Michele Ruggeri

Amanda Worthy Dombrowski

Stevan W. Djuric


A photo‐flow Norrish‐Yang cyclisation has been devised that delivers 3‐hydroxyazetidines in good yields. The high reproducibility and short residence times of the flow process enables easy scaling of the transformation allowing access to these valuable chemical entities at synthetically useful multi‐gram scales. A systematic exploration of the constituent structural components was undertaken allowing an understanding of the reactivity and functional group tolerance of the transformation.


Ruggeri, M., Dombrowski, A. W., Djuric, S. W., & Baxendale, I. R. (in press). Photochemical flow synthesis of 3‐hydroxyazetidines. ChemPhotoChem,

Journal Article Type Article
Acceptance Date Aug 1, 2019
Deposit Date Aug 8, 2019
Journal ChemPhotoChem.
Print ISSN 2367-0932
Publisher Wiley
Peer Reviewed Peer Reviewed
Public URL