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Photochemical flow synthesis of 3‐hydroxyazetidines

Ruggeri, Michele; Dombrowski, Amanda Worthy; Djuric, Stevan W.; Baxendale, Ian Richard

Authors

Michele Ruggeri

Amanda Worthy Dombrowski

Stevan W. Djuric



Abstract

A photo‐flow Norrish‐Yang cyclisation has been devised that delivers 3‐hydroxyazetidines in good yields. The high reproducibility and short residence times of the flow process enables easy scaling of the transformation allowing access to these valuable chemical entities at synthetically useful multi‐gram scales. A systematic exploration of the constituent structural components was undertaken allowing an understanding of the reactivity and functional group tolerance of the transformation.

Citation

Ruggeri, M., Dombrowski, A. W., Djuric, S. W., & Baxendale, I. R. (in press). Photochemical flow synthesis of 3‐hydroxyazetidines. ChemPhotoChem, https://doi.org/10.1002/cptc.201900188

Journal Article Type Article
Acceptance Date Aug 1, 2019
Deposit Date Aug 8, 2019
Journal ChemPhotoChem.
Print ISSN 2367-0932
Publisher Wiley
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1002/cptc.201900188
Public URL https://durham-repository.worktribe.com/output/1295699