A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives

Gambacorta, Guido; Apperley, David C.; Baxendale, Ian R.

Abstract

The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We have developed a one-pot procedure for their synthesis starting from simple isatins. The method employs cheap and easy-to-handle building blocks and allows easy isolation.

Citation

Gambacorta, G., Apperley, D. C., & Baxendale, I. R. (2020). A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives. Molecules, 25(9), Article 2160. https://doi.org/10.3390/molecules25092160

• Journal Article Type: Article
• Acceptance Date: Apr 30, 2020
• Online Publication Date: May 5, 2020
• Publication Date: May 1, 2020
• Deposit Date: May 27, 2020
• Publicly Available Date: May 27, 2020
• Journal: Molecules
• Electronic ISSN: 1420-3049
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 25
• Issue: 9
• Article Number: 2160
• DOI: https://doi.org/10.3390/molecules25092160
• Public URL: https://durham-repository.worktribe.com/output/1269861