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A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives

Gambacorta, Guido; Apperley, David C.; Baxendale, Ian R.

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Authors

Guido Gambacorta

David C. Apperley



Abstract

The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We have developed a one-pot procedure for their synthesis starting from simple isatins. The method employs cheap and easy-to-handle building blocks and allows easy isolation.

Citation

Gambacorta, G., Apperley, D. C., & Baxendale, I. R. (2020). A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives. Molecules, 25(9), Article 2160. https://doi.org/10.3390/molecules25092160

Journal Article Type Article
Acceptance Date Apr 30, 2020
Online Publication Date May 5, 2020
Publication Date May 1, 2020
Deposit Date May 27, 2020
Publicly Available Date May 27, 2020
Journal Molecules
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 25
Issue 9
Article Number 2160
DOI https://doi.org/10.3390/molecules25092160

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Published Journal Article (2.7 Mb)
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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
© This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.





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