Skip to main content

Research Repository

Advanced Search

Bright red aggregation-induced emission nanoparticles for multifunctional applications in cancer therapy

Zhang, Liping; Che, Weilong; Yang, Zhiyu; Liu, Xingman; Liu, Shi; Xie, Zhigang; Zhu, Dongxia; Su, Zhongmin; Tang, Ben Zhong; Bryce, Martin R.

Bright red aggregation-induced emission nanoparticles for multifunctional applications in cancer therapy Thumbnail


Authors

Liping Zhang

Weilong Che

Zhiyu Yang

Xingman Liu

Shi Liu

Zhigang Xie

Dongxia Zhu

Zhongmin Su

Ben Zhong Tang



Abstract

Developing multifunctional photosensitizers (PSs) is needed to effectively simplify cancer treatment, but it remains a big challenge. Here, two red-emitting AIE-active, donor–acceptor (D–A) PSs with small ΔEST and their AIE nanoparticles, are rationally designed and synthesized. The PS1 NPs exhibit bright red-emission with high quantum yield, appropriate 1O2 generation ability and good biocompatibility. More importantly, PS1 NPs can strongly light up the cytoplasm by gently shaking the cells for only 5 s at room temperature, indicating ultrafast staining and mild incubation conditions. In vitro and in vivo cell tracing demonstrate that PS1 NPs can track cells over 14 days, and effectively inhibit tumor growth upon irradiation. To the best of our knowledge, this work is the first example of a PS that integrates image-guided PDT, ultrafast staining and long-term tracing functions, demonstrating the “all-in-one” concept which offers great advantages for potential clinical applications

Citation

Zhang, L., Che, W., Yang, Z., Liu, X., Liu, S., Xie, Z., …Bryce, M. R. (2020). Bright red aggregation-induced emission nanoparticles for multifunctional applications in cancer therapy. Chemical Science, 11(9), 2369-2374. https://doi.org/10.1039/c9sc06310b

Journal Article Type Article
Acceptance Date Jan 22, 2020
Online Publication Date Jan 29, 2020
Publication Date Mar 7, 2020
Deposit Date Mar 25, 2020
Publicly Available Date Mar 25, 2020
Journal Chemical Science
Print ISSN 2041-6520
Electronic ISSN 2041-6539
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 11
Issue 9
Pages 2369-2374
DOI https://doi.org/10.1039/c9sc06310b

Files






You might also like



Downloadable Citations