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Development of a Continuous Photochemical Benzyne-Forming Process

Baumann, Marcus; Bracken, Cormac; Batsanov, Andrei S.

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Authors

Marcus Baumann

Cormac Bracken



Abstract

A continuous-flow process is presented that enables the safe generation and derivatization of benzyne under photochemical conditions. This is facilitated by a new high-power LED lamp emitting light at 365 nm. The resulting flow process effectively controls the release of gaseous by-products based on an adjustable backpressure regulator and delivers a series of heterocyclic products in a short residence time of 3 minutes. The robustness of this methodology is demonstrated for the rapid generation of benzotriazoles, 2H-indazoles and various furan-derived adducts, facilitating the preparation of these important heterocyclic scaffolds via a simple and readily scalable flow protocol.

Citation

Baumann, M., Bracken, C., & Batsanov, A. S. (2021). Development of a Continuous Photochemical Benzyne-Forming Process. SynOpen, 05(01), 29-35. https://doi.org/10.1055/s-0040-1706016

Journal Article Type Article
Acceptance Date Jan 7, 2021
Online Publication Date Feb 1, 2021
Publication Date 2021
Deposit Date Sep 8, 2021
Publicly Available Date Sep 8, 2021
Journal SynOpen
Electronic ISSN 2509-9396
Publisher Thieme Open
Peer Reviewed Peer Reviewed
Volume 05
Issue 01
Pages 29-35
DOI https://doi.org/10.1055/s-0040-1706016
Public URL https://durham-repository.worktribe.com/output/1242121

Files

Published Journal Article (Advance online version) (958 Kb)
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Publisher Licence URL
http://creativecommons.org/licenses/by-nc-nd/4.0/

Copyright Statement
Advance online version Open Access. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.






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