Development of a Continuous Photochemical Benzyne-Forming Process

Baumann, Marcus; Bracken, Cormac; Batsanov, Andrei S.

doi:10.1055/s-0040-1706016

Development of a Continuous Photochemical Benzyne-Forming Process

Baumann, Marcus; Bracken, Cormac; Batsanov, Andrei S.

Authors

Marcus Baumann

Cormac Bracken

Dr Andrei Batsanov a.s.batsanov@durham.ac.uk
Academic Visitor

Abstract

A continuous-flow process is presented that enables the safe generation and derivatization of benzyne under photochemical conditions. This is facilitated by a new high-power LED lamp emitting light at 365 nm. The resulting flow process effectively controls the release of gaseous by-products based on an adjustable backpressure regulator and delivers a series of heterocyclic products in a short residence time of 3 minutes. The robustness of this methodology is demonstrated for the rapid generation of benzotriazoles, 2H-indazoles and various furan-derived adducts, facilitating the preparation of these important heterocyclic scaffolds via a simple and readily scalable flow protocol.

Citation

Baumann, M., Bracken, C., & Batsanov, A. S. (2021). Development of a Continuous Photochemical Benzyne-Forming Process. SynOpen, 05(01), 29-35. https://doi.org/10.1055/s-0040-1706016

Journal Article Type	Article
Acceptance Date	Jan 7, 2021
Online Publication Date	Feb 1, 2021
Publication Date	2021
Deposit Date	Sep 8, 2021
Publicly Available Date	Sep 8, 2021
Journal	SynOpen
Publisher	Thieme Open
Peer Reviewed	Peer Reviewed
Volume	05
Issue	01
Pages	29-35
DOI	https://doi.org/10.1055/s-0040-1706016

Files

Published Journal Article (Advance online version) (958 Kb)
PDF

Publisher Licence URL
http://creativecommons.org/licenses/by-nc-nd/4.0/

Copyright Statement
Advance online version Open Access. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.