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Properties and Applications of Stimuli-Responsive Diacetylenes

Hall, Amy V.; Musa, Osama M.; Steed, Jonathan W.

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Dr Amy Hall
Leverhulme Early Career Fellow

Osama M. Musa


The topochemical reactivity of diacetylene monomers has long been established and involves the 1,4-addition polymerization reaction. This reaction is governed by well-defined parameters that allow the synthesis of diacetylene polymers. Polydiacetylenes are conjugated polymers that display unique colorimetric and fluorescent transitions when they are exposed to a range of stimuli, allowing them to be easily exploited in biosensors, chemosensors, and radiochromic dosimeters. In this review, we summarize recent work on polydiacetylene systems, focusing on examples involving 10,12-pentacosadiynoic acid (PCDA) that can be structured as polymerized vesicles, films, gels, and powders. Synthetic derivatives of PCDA are also reviewed, along with the effect of incorporating guest molecules to a diacetylene system and establishing the important relationship between reversible thermochromism and noncovalent interactions.


Hall, A. V., Musa, O. M., & Steed, J. W. (2021). Properties and Applications of Stimuli-Responsive Diacetylenes. Crystal Growth and Design, 21(6), 3614-3638.

Journal Article Type Article
Online Publication Date May 10, 2021
Publication Date Jun 2, 2021
Deposit Date Jul 29, 2021
Publicly Available Date May 10, 2022
Journal Crystal Growth and Design
Print ISSN 1528-7483
Electronic ISSN 1528-7505
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 21
Issue 6
Pages 3614-3638


Accepted Journal Article (3.5 Mb)

Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see

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