Evon Low
How good is the evidence that cellular senescence causes skin ageing?
Low, Evon; Alimohammadiha, Ghazaleh; Smith, Lucy A.; Costello, Lydia F.; Przyborski, Stefan A.; von Zglinicki, Thomas; Miwa, Satomi
Authors
Ghazaleh Alimohammadiha
Dr Lucy Smith l.a.smith2@durham.ac.uk
Academic Visitor
Lydia F. Costello
Professor Stefan Przyborski stefan.przyborski@durham.ac.uk
Deputy Provost
Thomas von Zglinicki
Satomi Miwa
Abstract
Skin is the largest organ of the body with important protective functions, which become compromised with time due to both intrinsic and extrinsic ageing processes. Cellular senescence is the primary ageing process at cell level, associated with loss of proliferative capacity, mitochondrial dysfunction and significantly altered patterns of expression and secretion of bioactive molecules. Intervention experiments have proven cell senescence as a relevant cause of ageing in many organs. In case of skin, accumulation of senescence in all major compartments with ageing is well documented and might be responsible for most, if not all, the molecular changes observed during ageing. Incorporation of senescent cells into in-vitro skin models (specifically 3D full thickness models) recapitulates changes typically associated with skin ageing. However, crucial evidence is still missing. A beneficial effect of senescent cell ablation on skin ageing has so far only been shown following rather unspecific interventions or in transgenic mouse models. We conclude that evidence for cellular senescence as a relevant cause of intrinsic skin ageing is highly suggestive but not yet completely conclusive.
Citation
Low, E., Alimohammadiha, G., Smith, L. A., Costello, L. F., Przyborski, S. A., von Zglinicki, T., & Miwa, S. (2021). How good is the evidence that cellular senescence causes skin ageing?. Ageing Research Reviews, 71, https://doi.org/10.1016/j.arr.2021.101456
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 31, 2021 |
Online Publication Date | Sep 3, 2021 |
Publication Date | 2021-11 |
Deposit Date | Sep 8, 2021 |
Publicly Available Date | Oct 22, 2021 |
Journal | Ageing Research Reviews |
Print ISSN | 1568-1637 |
Electronic ISSN | 1872-9649 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 71 |
DOI | https://doi.org/10.1016/j.arr.2021.101456 |
Public URL | https://durham-repository.worktribe.com/output/1235507 |
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Copyright Statement
© 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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