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Alkali Metal Salts of 10,12-Pentacosadiynoic Acid and Their Dosimetry Applications

Hall, Amy V.; Musa, Osama M.; Hood, David K.; Apperley, David C.; Yufit, Dmitry S.; Steed, Jonathan W.

Alkali Metal Salts of 10,12-Pentacosadiynoic Acid and Their Dosimetry Applications Thumbnail


Dr Amy Hall
Leverhulme Early Career Fellow

Osama M. Musa

David K. Hood

David C. Apperley


Wide-dose-range 2D radiochromic films for radiotherapy, such as GAFchromic EBT, are based on the lithium salt of 10,12-pentacosadiynoic acid (Li-PCDA) as the photosensitive component. We show that there are two solid forms of Li-PCDA—a monohydrated form A and an anhydrous form B. The form used in commercial GAFchromic films is form A due to its short needle-shaped crystals, which provide favorable coating properties. Form B provides an enhanced photoresponse compared to that of form A, but adopts a long needle crystal morphology, which is difficult to process. The two forms were characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, CP-MAS 13C solid-state NMR spectroscopy, and thermogravimetric analysis. In sum, these data suggest a chelating bridging bidentate coordination mode for the lithium ions. The sodium salt of PCDA (Na-PCDA) is also reported, which is an ionic cocrystal with a formula of Na+PCDA–·3PCDA. The PCDA and PCDA– ligands display monodentate and bridging bidentate coordination to the sodium ion in contrast to the coordination sphere of the Li-PCDA forms. In contrast to its lithium analogues, Na-PCDA is photostable.


Hall, A. V., Musa, O. M., Hood, D. K., Apperley, D. C., Yufit, D. S., & Steed, J. W. (2021). Alkali Metal Salts of 10,12-Pentacosadiynoic Acid and Their Dosimetry Applications. Crystal Growth and Design, 21(4), 2416-2422.

Journal Article Type Article
Online Publication Date Mar 25, 2021
Publication Date Apr 7, 2021
Deposit Date Oct 27, 2021
Publicly Available Date Mar 25, 2022
Journal Crystal Growth and Design
Print ISSN 1528-7483
Electronic ISSN 1528-7505
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 21
Issue 4
Pages 2416-2422


Accepted Journal Article (1.2 Mb)

Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see

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