Lanthanide luminescence from supramolecular hydrogels consisting of bio-conjugated picolinic-acid-based guanosine quadruplexes

Kotova, Oxana; O’Reilly, Ciaran; Barwich, Sebastian T.; Mackenzie, Lewis E.; Lynes, Amy D.; Savyasachi, Aramballi J.; Ruether, Manuel; Pal, Robert; Möbius, Matthias E.; Gunnlaugsson, Thorfinnur

Abstract

The formation of bio-inspired healable lanthanide luminescent hydrogels is detailed. These materials are composed of K(I)-stabilized guanosine quadruplexes (G4) that were bio-conjugated to mannose-derived picolinic acid ligand 1 using boric acid chemistry (G4-1). The supramolecular self-assembly between G4-1 and europium (Eu(III)) was confirmed, including the use of time-gated luminescence spectroscopy. The most stable hydrogel was formed when the ratio between 1 and Eu(III) was 1:1, and this gel was found to retain a helical column. The obtained gel samples were further characterized using techniques, such as scanning electron microscopy (SEM), circular dichroism (CD), and luminescence spectroscopy. We demonstrate that a Eu(III)-centered circularly polarized luminescence (CPL) signal from guanosine hydrogels can be observed even via long-range interaction, whereas the rheology of these gels exhibits their healable properties.

Citation

Kotova, O., O’Reilly, C., Barwich, S. T., Mackenzie, L. E., Lynes, A. D., Savyasachi, A. J., Ruether, M., Pal, R., Möbius, M. E., & Gunnlaugsson, T. (2022). Lanthanide luminescence from supramolecular hydrogels consisting of bio-conjugated picolinic-acid-based guanosine quadruplexes. Chem, 8(5), 1395-1414. https://doi.org/10.1016/j.chempr.2022.01.015

• Journal Article Type: Article
• Acceptance Date: Jan 21, 2022
• Online Publication Date: Feb 15, 2022
• Publication Date: May 12, 2022
• Deposit Date: Mar 30, 2022
• Journal: Chem
• Print ISSN: 2451-9308
• Electronic ISSN: 2451-9294
• Publisher: Cell Press
• Peer Reviewed: Peer Reviewed
• Volume: 8
• Issue: 5
• Pages: 1395-1414
• DOI: https://doi.org/10.1016/j.chempr.2022.01.015
• Public URL: https://durham-repository.worktribe.com/output/1208954