Maria Niarchou
Genome-wide association study of musical beat synchronization demonstrates high polygenicity
Niarchou, Maria; Gustavson, Daniel E.; Sathirapongsasuti, J. Fah; Anglada-Tort, Manuel; Eising, Else; Bell, Eamonn; McArthur, Evonne; Straub, Peter; Aslibekyan, Stella; Auton, Adam; Bell, Robert K.; Bryc, Katarzyna; Clark, Sarah K.; Elson, Sarah L.; Fletez-Brant, Kipper; Fontanillas, Pierre; Furlotte, Nicholas A.; Gandhi, Pooja M.; Heilbron, Karl; Hicks, Barry; Huber, Karen E.; Jewett, Ethan M.; Jiang, Yunxuan; Kleinman, Aaron; Lin, Keng-Han; Litterman, Nadia K.; McCreight, Jey C.; McIntyre, Matthew H.; McManus, Kimberly F.; Mountain, Joanna L.; Mozaffari, Sahar V.; Nandakumar, Priyanka; Noblin, Elizabeth S.; Northover, Carrie A.M.; O’Connell, Jared; Pitts, Steven J.; Poznik, G. David; Shastri, Anjali J.; Shelton, Janie F.; Shringarpure, Suyash; Tian, Chao; Tung, Joyce Y.; Tunney, Robert J.; Vacic, Vladimir; Wang, Xin; McAuley, J. Devin; Capra, John A.; Ullén, Fredrik; Creanza, Nicole; Mosing, Miriam A.; Hinds, David A.; Davis, Lea K.; Jacoby, Nori; Gordon, Reyna L.
Authors
Daniel E. Gustavson
J. Fah Sathirapongsasuti
Manuel Anglada-Tort
Else Eising
Dr Eamonn Bell eamonn.bell@durham.ac.uk
Assistant Professor
Evonne McArthur
Peter Straub
Stella Aslibekyan
Adam Auton
Dr Eamonn Bell eamonn.bell@durham.ac.uk
Assistant Professor
Katarzyna Bryc
Sarah K. Clark
Sarah L. Elson
Kipper Fletez-Brant
Pierre Fontanillas
Nicholas A. Furlotte
Pooja M. Gandhi
Karl Heilbron
Barry Hicks
Karen E. Huber
Ethan M. Jewett
Yunxuan Jiang
Aaron Kleinman
Keng-Han Lin
Nadia K. Litterman
Jey C. McCreight
Matthew H. McIntyre
Kimberly F. McManus
Joanna L. Mountain
Sahar V. Mozaffari
Priyanka Nandakumar
Elizabeth S. Noblin
Carrie A.M. Northover
Jared O’Connell
Steven J. Pitts
G. David Poznik
Anjali J. Shastri
Janie F. Shelton
Suyash Shringarpure
Chao Tian
Joyce Y. Tung
Robert J. Tunney
Vladimir Vacic
Xin Wang
J. Devin McAuley
John A. Capra
Fredrik Ullén
Nicole Creanza
Miriam A. Mosing
David A. Hinds
Lea K. Davis
Nori Jacoby
Reyna L. Gordon
Abstract
Moving in synchrony to the beat is a fundamental component of musicality. Here we conducted a genome-wide association study to identify common genetic variants associated with beat synchronization in 606,825 individuals. Beat synchronization exhibited a highly polygenic architecture, with 69 loci reaching genome-wide significance (P < 5 × 10−8) and single-nucleotide-polymorphism-based heritability (on the liability scale) of 13%–16%. Heritability was enriched for genes expressed in brain tissues and for fetal and adult brain-specific gene regulatory elements, underscoring the role of central-nervous-system-expressed genes linked to the genetic basis of the trait. We performed validations of the self-report phenotype (through separate experiments) and of the genome-wide association study (polygenic scores for beat synchronization were associated with patients algorithmically classified as musicians in medical records of a separate biobank). Genetic correlations with breathing function, motor function, processing speed and chronotype suggest shared genetic architecture with beat synchronization and provide avenues for new phenotypic and genetic explorations.
Citation
Niarchou, M., Gustavson, D. E., Sathirapongsasuti, J. F., Anglada-Tort, M., Eising, E., Bell, E., …Gordon, R. L. (2022). Genome-wide association study of musical beat synchronization demonstrates high polygenicity. Nature Human Behaviour, 6(9), 1292-1309. https://doi.org/10.1038/s41562-022-01359-x
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 21, 2022 |
Online Publication Date | Jun 16, 2022 |
Publication Date | 2022-09 |
Deposit Date | Jun 23, 2022 |
Publicly Available Date | Feb 8, 2023 |
Journal | Nature Human Behaviour |
Publisher | Nature Research |
Peer Reviewed | Peer Reviewed |
Volume | 6 |
Issue | 9 |
Pages | 1292-1309 |
DOI | https://doi.org/10.1038/s41562-022-01359-x |
Public URL | https://durham-repository.worktribe.com/output/1201048 |
Related Public URLs | https://www.biorxiv.org/content/10.1101/836197v3 |
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