Skip to main content

Research Repository

Advanced Search

Copper Cytotoxicity: Cellular Casualties of Noncognate Coordination Chemistry

O’Hern, Charlotte I.Z.; Djoko, Karrera Y.

Copper Cytotoxicity: Cellular Casualties of Noncognate Coordination Chemistry Thumbnail


Authors

Charlotte I.Z. O’Hern



Abstract

Copper (Cu) is an essential micronutrient for cells, but in excess it is cytotoxic. How Cu is cytotoxic is the subject of recent work by L. Zuily, N. Lahrach, R. Fassler, O. Genest, et al. (mBio 13:e03251-21, 2022, https://doi.org/10.1128/mbio.03251-21). Using Escherichia coli as the model cell, the work shows that anoxic cells accumulate larger amounts of Cu than do oxic cells. Accordingly, Cu is more cytotoxic under anoxic than oxic conditions. The work further shows that Cu cytotoxicity in anoxic bacteria is associated with increased intracellular protein aggregation. The mechanistic details remain as open questions, but these questions highlight that a fundamental understanding of Cu speciation and availability in cells is essential to uncover the cellular consequences of Cu cytotoxicity.

Citation

O’Hern, C. I., & Djoko, K. Y. (2022). Copper Cytotoxicity: Cellular Casualties of Noncognate Coordination Chemistry. mBio, 13(3), e00434-22. https://doi.org/10.1128/mbio.00434-22

Journal Article Type Article
Online Publication Date May 23, 2022
Publication Date 2022-06
Deposit Date Jul 26, 2022
Publicly Available Date Jul 26, 2022
Journal mBio
Print ISSN 2161-2129
Publisher American Society for Microbiology
Peer Reviewed Peer Reviewed
Volume 13
Issue 3
Article Number e00434-22
Pages e00434-22
DOI https://doi.org/10.1128/mbio.00434-22

Files







You might also like



Downloadable Citations