AIE-active iridium(iii) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy

Liu, Shengnan; Han, Jiahong; Chang, Yulei; Wang, Weijin; Wang, Runlin; Wang, Ziwei; Li, Guangzhe; Zhu, Dongxia; Bryce, Martin R.

Abstract

The integration of an aggregation induced emission (AIE)-active Ir(III) complex and upconversion nanoparticles (UCNPs) has achieved a NIR-irradiated photosensitizer (PS), UCNPs@Ir-2-N. This PS has satisfactory biocompatibility, excellent phototoxicity, good accumulation in cells and high 1O2 generation ability, thereby effectively killing 4T1 mouse cancer cells in vitro. This work has potential for future photodynamic therapy (PDT) applications.

Citation

Liu, S., Han, J., Chang, Y., Wang, W., Wang, R., Wang, Z., Li, G., Zhu, D., & Bryce, M. R. (2022). AIE-active iridium(iii) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy. Chemical Communications, 58(72), 10056 - 10059. https://doi.org/10.1039/d2cc03622c

• Journal Article Type: Article
• Acceptance Date: Aug 11, 2022
• Online Publication Date: Aug 22, 2022
• Publication Date: 2022
• Deposit Date: Sep 15, 2022
• Publicly Available Date: Sep 15, 2022
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 58
• Issue: 72
• Pages: 10056 - 10059
• DOI: https://doi.org/10.1039/d2cc03622c
• Public URL: https://durham-repository.worktribe.com/output/1191221