Frederike Cosima Oertel
Diagnostic value of intereye difference metrics for optic neuritis in aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders
Oertel, Frederike Cosima; Zimmermann, Hanna G; Motamedi, Seyedamirhosein; Chien, Claudia; Aktas, Orhan; Albrecht, Philipp; Ringelstein, Marius; Dcunha, Anitha; Pandit, Lekha; Martinez-Lapiscina, Elena H; Sanchez-Dalmau, Bernardo; Villoslada, Pablo; Palace, Jacqueline; Roca-Fernández, Adriana; Leite, Maria Isabel; Sharma, Srilakshmi M; Leocani, Letizia; Pisa, Marco; Radaelli, Marta; Lana-Peixoto, Marco Aurélio; Fontenelle, Mariana Andrade; Havla, Joachim; Ashtari, Fereshteh; Kafieh, Rahele; Dehghani, Alireza; Pourazizi, Mohsen; Marignier, Romain; Cobo-Calvo, Alvaro; Asgari, Nasrin; Jacob, Anu; Huda, Saif; Mao-Draayer, Yang; Green, Ari J; Kenney, Rachel; Yeaman, Michael R; Smith, Terry J; Cook, Lawrence; Brandt, Alexander U; Paul, Friedemann; Petzold, Axel
Authors
Hanna G Zimmermann
Seyedamirhosein Motamedi
Claudia Chien
Orhan Aktas
Philipp Albrecht
Marius Ringelstein
Anitha Dcunha
Lekha Pandit
Elena H Martinez-Lapiscina
Bernardo Sanchez-Dalmau
Pablo Villoslada
Jacqueline Palace
Adriana Roca-Fernández
Maria Isabel Leite
Srilakshmi M Sharma
Letizia Leocani
Marco Pisa
Marta Radaelli
Marco Aurélio Lana-Peixoto
Mariana Andrade Fontenelle
Joachim Havla
Fereshteh Ashtari
Dr Raheleh Kafieh raheleh.kafieh@durham.ac.uk
Assistant Professor
Alireza Dehghani
Mohsen Pourazizi
Romain Marignier
Alvaro Cobo-Calvo
Nasrin Asgari
Anu Jacob
Saif Huda
Yang Mao-Draayer
Ari J Green
Rachel Kenney
Michael R Yeaman
Terry J Smith
Lawrence Cook
Alexander U Brandt
Friedemann Paul
Axel Petzold
Abstract
Background: The novel optic neuritis (ON) diagnostic criteria include intereye differences (IED) of optical coherence tomography (OCT) parameters. IED has proven valuable for ON diagnosis in multiple sclerosis but has not been evaluated in aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders (AQP4+NMOSD). We evaluated the diagnostic accuracy of intereye absolute (IEAD) and percentage difference (IEPD) in AQP4+NMOSD after unilateral ON >6 months before OCT as compared with healthy controls (HC). Methods: Twenty-eight AQP4+NMOSD after unilateral ON (NMOSD-ON), 62 HC and 45 AQP4+NMOSD without ON history (NMOSD-NON) were recruited by 13 centres as part of the international Collaborative Retrospective Study on retinal OCT in Neuromyelitis Optica study. Mean thickness of peripapillary retinal nerve fibre layer (pRNFL) and macular ganglion cell and inner plexiform layer (GCIPL) were quantified by Spectralis spectral domain OCT. Threshold values of the ON diagnostic criteria (pRNFL: IEAD 5 µm, IEPD 5%; GCIPL: IEAD: 4 µm, IEPD: 4%) were evaluated using receiver operating characteristics and area under the curve (AUC) metrics. Results: The discriminative power was high for NMOSD-ON versus HC for IEAD (pRNFL: AUC 0.95, specificity 82%, sensitivity 86%; GCIPL: AUC 0.93, specificity 98%, sensitivity 75%) and IEPD (pRNFL: AUC 0.96, specificity 87%, sensitivity 89%; GCIPL: AUC 0.94, specificity 96%, sensitivity 82%). The discriminative power was high/moderate for NMOSD-ON versus NMOSD-NON for IEAD (pRNFL: AUC 0.92, specificity 77%, sensitivity 86%; GCIP: AUC 0.87, specificity 85%, sensitivity 75%) and for IEPD (pRNFL: AUC 0.94, specificity 82%, sensitivity 89%; GCIP: AUC 0.88, specificity 82%, sensitivity 82%). Conclusions: Results support the validation of the IED metrics as OCT parameters of the novel diagnostic ON criteria in AQP4+NMOSD.
Citation
Oertel, F. C., Zimmermann, H. G., Motamedi, S., Chien, C., Aktas, O., Albrecht, P., Ringelstein, M., Dcunha, A., Pandit, L., Martinez-Lapiscina, E. H., Sanchez-Dalmau, B., Villoslada, P., Palace, J., Roca-Fernández, A., Leite, M. I., Sharma, S. M., Leocani, L., Pisa, M., Radaelli, M., Lana-Peixoto, M. A., …Petzold, A. (2023). Diagnostic value of intereye difference metrics for optic neuritis in aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorders. Journal of Neurology, Neurosurgery and Psychiatry, 94(7), 560-566. https://doi.org/10.1136/jnnp-2022-330608
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 9, 2023 |
Online Publication Date | Feb 21, 2023 |
Publication Date | Jun 14, 2023 |
Deposit Date | Mar 3, 2023 |
Publicly Available Date | Mar 3, 2023 |
Journal | Journal of Neurology, Neurosurgery & Psychiatry |
Print ISSN | 0022-3050 |
Electronic ISSN | 1468-330X |
Publisher | BMJ Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 94 |
Issue | 7 |
Pages | 560-566 |
DOI | https://doi.org/10.1136/jnnp-2022-330608 |
Public URL | https://durham-repository.worktribe.com/output/1177812 |
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Online First © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
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