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Conserved domains can be found across distinct phage defence systems

Mariano, G.; Blower, T.R.

Conserved domains can be found across distinct phage defence systems Thumbnail


Authors

G. Mariano



Abstract

Bacteria are continuously exposed to predation from bacteriophages (phages) and, in response, have evolved a broad range of defence systems. These systems can prevent the replication of phages and other mobile genetic elements (MGE). Defence systems are often encoded together in genomic loci defined as “defence islands”, a tendency that has been extensively exploited to identify novel antiphage systems. In the last few years, >100 new antiphage systems have been discovered, and some display homology to components of the immune systems of plants and animals. In many instances, prediction tools have found domains with similar predicted functions present as different combinations within distinct antiphage systems. In this Perspective Article, we review recent reports describing the discovery and the predicted domain composition of several novel antiphage systems. We discuss several examples of similar protein domains adopted by different antiphage systems, including domains of unknown function (DUFs), domains involved in nucleic acid recognition and degradation, and domains involved in NAD+ depletion. We further discuss the potential evolutionary advantages that could have driven the independent acquisition of these domains by different antiphage systems.

Citation

Mariano, G., & Blower, T. (2023). Conserved domains can be found across distinct phage defence systems. Molecular Microbiology, 120(1), 45-53. https://doi.org/10.1111/mmi.15047

Journal Article Type Article
Acceptance Date Feb 16, 2023
Online Publication Date Feb 24, 2023
Publication Date 2023-07
Deposit Date Mar 10, 2023
Publicly Available Date Mar 10, 2023
Journal Molecular Microbiology
Print ISSN 0950-382X
Electronic ISSN 1365-2958
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 120
Issue 1
Pages 45-53
DOI https://doi.org/10.1111/mmi.15047
Public URL https://durham-repository.worktribe.com/output/1177400

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Published Journal Article (EarlyView) (266 Kb)
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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/

Copyright Statement
EarlyView © 2023 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.






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