Orsolya Fölsz
Adult-born neurons add flexibility to hippocampal memories
Fölsz, Orsolya; Trouche, Stéphanie; Croset, Vincent
Abstract
Although most neurons are generated embryonically, neurogenesis is maintained at low rates in specific brain areas throughout adulthood, including the dentate gyrus of the mammalian hippocampus. Episodic-like memories encoded in the hippocampus require the dentate gyrus to decorrelate similar experiences by generating distinct neuronal representations from overlapping inputs (pattern separation). Adult-born neurons integrating into the dentate gyrus circuit compete with resident mature cells for neuronal inputs and outputs, and recruit inhibitory circuits to limit hippocampal activity. They display transient hyperexcitability and hyperplasticity during maturation, making them more likely to be recruited by any given experience. Behavioral evidence suggests that adult-born neurons support pattern separation in the rodent dentate gyrus during encoding, and they have been proposed to provide a temporal stamp to memories encoded in close succession. The constant addition of neurons gradually degrades old connections, promoting generalization and ultimately forgetting of remote memories in the hippocampus. This makes space for new memories, preventing saturation and interference. Overall, a small population of adult-born neurons appears to make a unique contribution to hippocampal information encoding and removal. Although several inconsistencies regarding the functional relevance of neurogenesis remain, in this review we argue that immature neurons confer a unique form of transience on the dentate gyrus that complements synaptic plasticity to help animals flexibly adapt to changing environments.
Citation
Fölsz, O., Trouche, S., & Croset, V. (2023). Adult-born neurons add flexibility to hippocampal memories. Frontiers in Neuroscience, 17, Article 1128623. https://doi.org/10.3389/fnins.2023.1128623
Journal Article Type | Article |
---|---|
Acceptance Date | Jan 30, 2023 |
Online Publication Date | Feb 15, 2023 |
Publication Date | 2023 |
Deposit Date | Mar 11, 2023 |
Publicly Available Date | Apr 28, 2023 |
Journal | Frontiers in Neuroscience |
Print ISSN | 1662-4548 |
Electronic ISSN | 1662-453X |
Publisher | Frontiers Media |
Peer Reviewed | Peer Reviewed |
Volume | 17 |
Article Number | 1128623 |
DOI | https://doi.org/10.3389/fnins.2023.1128623 |
Public URL | https://durham-repository.worktribe.com/output/1177263 |
Files
Published Journal Article
(2.1 Mb)
PDF
Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/
Copyright Statement
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
You might also like
Gliotransmission of D-serine promotes thirst-directed behaviors in Drosophila
(2022)
Journal Article
Drosophila Ionotropic Receptor 25a mediates circadian clock resetting by temperature
(2015)
Journal Article
Draft genome of the red harvester ant Pogonomyrmex barbatus
(2011)
Journal Article
Downloadable Citations
About Durham Research Online (DRO)
Administrator e-mail: dro.admin@durham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search