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Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis

Murray, Jacob; Hodgson, David R.W.; O’Donoghue, AnnMarie C.

Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis Thumbnail


Authors

Jacob Murray



Abstract

Many enzymes work in tandem with small molecule cofactors, which have inspired organocatalyst designs. Chemical modification of cofactor scaffolds has increased organocatalytic reactivity and reaction scope. This synopsis presents a selection of recent advances in the use of cofactors (native and mimics) in organocatalysis and biocatalysis. We aim to highlight the benefits of combining fundamental knowledge gained in both bio- and organo-catalysis for asymmetric biocatalysis.

Journal Article Type Article
Online Publication Date Apr 26, 2023
Publication Date 2023
Deposit Date May 16, 2023
Publicly Available Date May 16, 2023
Journal The Journal of Organic Chemistry
Print ISSN 0022-3263
Electronic ISSN 1520-6904
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1021/acs.joc.2c02747
Public URL https://durham-repository.worktribe.com/output/1174437

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