Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis

Murray, Jacob; Hodgson, David R.W.; O’Donoghue, AnnMarie C.

Abstract

Many enzymes work in tandem with small molecule cofactors, which have inspired organocatalyst designs. Chemical modification of cofactor scaffolds has increased organocatalytic reactivity and reaction scope. This synopsis presents a selection of recent advances in the use of cofactors (native and mimics) in organocatalysis and biocatalysis. We aim to highlight the benefits of combining fundamental knowledge gained in both bio- and organo-catalysis for asymmetric biocatalysis.

Citation

Murray, J., Hodgson, D. R., & O’Donoghue, A. C. (2023). Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis. Journal of Organic Chemistry, 88(12), 7619–7629. https://doi.org/10.1021/acs.joc.2c02747

• Journal Article Type: Article
• Acceptance Date: Mar 26, 2023
• Online Publication Date: Apr 26, 2023
• Publication Date: Apr 26, 2023
• Deposit Date: May 16, 2023
• Publicly Available Date: May 16, 2023
• Journal: The Journal of Organic Chemistry
• Print ISSN: 0022-3263
• Electronic ISSN: 1520-6904
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 88
• Issue: 12
• Pages: 7619–7629
• DOI: https://doi.org/10.1021/acs.joc.2c02747
• Public URL: https://durham-repository.worktribe.com/output/1174437