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Can uptake of childhood influenza immunisation through schools and GP practices be increased through behaviourally-informed invitation letters and reminders: two pragmatic randomized controlled trials

Howell-Jones, Rebecca; Gold, Natalie; Bowen, Sarah; Bunten, Amanda; Tan, Karen; Saei, Ayoub; Jones, Sarah; MacDonald, Pauline; Watson, Robin; Bennett, Kirsty F.; Chadborn, Tim

Can uptake of childhood influenza immunisation through schools and GP practices be increased through behaviourally-informed invitation letters and reminders: two pragmatic randomized controlled trials Thumbnail


Authors

Rebecca Howell-Jones

Natalie Gold

Sarah Bowen

Amanda Bunten

Karen Tan

Ayoub Saei

Sarah Jones

Pauline MacDonald

Robin Watson robin.o.watson@durham.ac.uk
PGR Student Doctor of Philosophy

Kirsty F. Bennett

Tim Chadborn



Abstract

The UK is rolling out a national childhood influenza immunisation programme for children, delivered through primary care and schools. Behaviourally-informed letters and reminders have been successful at increasing uptake of other public health interventions. Therefore, we investigated the effects of a behaviourally-informed letter on uptake of the vaccine at GP practices, and of a letter and a reminder (SMS/ email) on uptake at schools. Methods and results Study 1 was a cluster-randomised parallel trial of 21,786 two- and three-year olds in 250 GP practices, conducted during flu season (September to January inclusive) 2016/7. The intervention was a centrally-sent behaviourally-informed invitation letter, control was usual care. The proportion of two- and three-year olds in each practice who received a vaccination by 31st January 2017 was 23.4% in the control group compared to 37.1% in the intervention group (OR = 1.93; 95% CI = 1.82, 2.05, p <  0.001). Study 2 was a 2 (behavioural letter vs standard letter) × 2 (reminder vs no reminder) factorial trial of 1108 primary schools which included 3010 school years 1–3. Letters were sent to parents from providers, and reminders sent to parents from the schools. In the standard-letter-no-reminder arm, an average of 61.6% of eligible children in each school year were vaccinated, compared to 61.9% in the behavioural-letter-no-reminder arm, 63.5% in the standard-letter-plus-reminder arm, and 62.9% in the behavioural-letter-plus reminder condition, F(3, 2990) = 2.68, p = 0.046. In a multi-level model, with demographic variables as fixed effects, the proportion of eligible students in the school year who were vaccinated increased with the reminder, β = 0.086 (0.041), p <  0.036, but there was no effect of the letter nor any interaction effect. Conclusion Sending a behaviourally informed invitation letter can increase uptake of childhood influenza vaccines at the GP surgery compared to usual practice. A reminder SMS or email can increase uptake of the influenza vaccine in schools, but the effect size was minimal.

Citation

Howell-Jones, R., Gold, N., Bowen, S., Bunten, A., Tan, K., Saei, A., …Chadborn, T. (2023). Can uptake of childhood influenza immunisation through schools and GP practices be increased through behaviourally-informed invitation letters and reminders: two pragmatic randomized controlled trials. BMC Public Health, 23(1), Article 143. https://doi.org/10.1186/s12889-022-14439-4

Journal Article Type Article
Acceptance Date Oct 25, 2022
Online Publication Date Jan 20, 2023
Publication Date 2023
Deposit Date May 31, 2023
Publicly Available Date Jun 6, 2023
Journal BMC Public Health
Publisher BioMed Central
Peer Reviewed Peer Reviewed
Volume 23
Issue 1
Article Number 143
DOI https://doi.org/10.1186/s12889-022-14439-4

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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.






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