Mapping the Evolution of Activity-Based Protein Profiling: A Bibliometric Review

Porta, Exequiel Oscar Jesus

Abstract

Activity-based protein profiling (ABPP) is a chemoproteomic approach that employs small-molecule probes to directly evaluate protein functionality within complex proteomes. This technology has proven to be a potent strategy for mapping ligandable sites in organisms and has significantly impacted drug discovery processes by enabling the development of highly selective small-molecule inhibitors and the identification of new therapeutic molecular targets. Despite being nearly a quarter of a century old as a chemoproteomic tool, ABPP has yet to undergo a bibliometric analysis. In order to gauge its scholarly impact and evolution, a bibliometric analysis was performed, comparing all 1919 reported articles with the articles published in the last five years. Through a comprehensive data analysis, including a 5-step workflow, the most influential articles were identified, and their bibliometric parameters were determined. The 1919 analyzed articles span from 1999 to 2022, providing a comprehensive overview of the historical and current state of ABPP research. This analysis presents, for the first time, the characteristics of the most influential ABPP articles, offering valuable insight into the research conducted in this field and its potential future directions. The findings underscore the crucial role of ABPP in drug discovery and novel therapeutic target identification, as well as the need for continued advancements in the development of novel chemical probes and proteomic technologies to further expand the utility of ABPP.

Citation

Porta, E. O. J. (2023). Mapping the Evolution of Activity-Based Protein Profiling: A Bibliometric Review. Advanced Pharmaceutical Bulletin, 13(4), 639-645. https://doi.org/10.34172/apb.2023.082

• Journal Article Type: Editorial
• Acceptance Date: May 17, 2023
• Online Publication Date: May 20, 2023
• Publication Date: Nov 1, 2023
• Deposit Date: Jun 20, 2023
• Publicly Available Date: Dec 19, 2023
• Journal: Advanced Pharmaceutical Bulletin
• Print ISSN: 2228-5881
• Electronic ISSN: 2251-7308
• Publisher: Tabriz University of Medical Sciences
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Issue: 4
• Pages: 639-645
• DOI: https://doi.org/10.34172/apb.2023.082
• Keywords: drug discovery, Bibliometric Analysis, Activity-based Probes, Chemical Probes, Activity-based Protein Profiling, Affinity-based Probes
• Public URL: https://durham-repository.worktribe.com/output/1171211
• PMID: 38022804