Systematic study of 1,2,3-triazolyl sterols for the development of new drugs against parasitic Neglected Tropical Diseases

Porta, Exequiel O.J.; Ballari, María Sol; Carlucci, Renzo; Wilkinson, Shane; Ma, Guoyi; Tekwani, Babu L.; Labadie, Guillermo R.

Abstract

A series of thirty 1,2,3-triazolylsterols, inspired by azasterols with proven antiparasitic activity, were prepared by a stereocontrolled synthesis. Ten of these compounds constitute chimeras/hybrids of 22,26-azasterol (AZA) and 1,2,3-triazolyl azasterols. The entire library was assayed against the kinetoplastid parasites Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei, the causatives agents for visceral leishmaniasis, Chagas disease, and sleeping sickness, respectively. Most of the compounds were active at submicromolar/nanomolar concentrations with high selectivity index, when compared to their cytotoxicity against mammalian cells. Analysis of in silico physicochemical properties were conducted to rationalize the activities against the neglected tropical disease pathogens. The analogs with selective activity against L. donovani (E4, IC50 0.78 μM), T brucei (E1, IC50 0.12 μM) and T. cruzi (B1– IC50 0.33 μM), and the analogs with broad-spectrum antiparasitic activities against the three kinetoplastid parasites (B1 and B3), may be promising leads for further development as selective or broad-spectrum antiparasitic drugs.

Citation

Porta, E. O., Ballari, M. S., Carlucci, R., Wilkinson, S., Ma, G., Tekwani, B. L., & Labadie, G. R. (2023). Systematic study of 1,2,3-triazolyl sterols for the development of new drugs against parasitic Neglected Tropical Diseases. European Journal of Medicinal Chemistry, 254, Article 115378. https://doi.org/10.1016/j.ejmech.2023.115378

• Journal Article Type: Article
• Acceptance Date: Apr 12, 2023
• Online Publication Date: Apr 13, 2023
• Publication Date: Jun 5, 2023
• Deposit Date: Jun 20, 2023
• Journal: European Journal of Medicinal Chemistry
• Print ISSN: 0223-5234
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 254
• Article Number: 115378
• DOI: https://doi.org/10.1016/j.ejmech.2023.115378
• Public URL: https://durham-repository.worktribe.com/output/1169453