A Clinically Applicable Strategy for Estimation of In Vivo Ventricular Wall Elasticity

Xu, Jing; Simon, Marc A; Wong, Timothy C; Brigham, John C

Abstract

A clinically applicable approach to estimate the in vivo elastic material properties of the heart wall is presented. This strategy utilizes a patient-specific bi-ventricle mechanical model within an optimization-type inverse problem solution procedure that accounts for the rigid body motion of the heart to estimate elastic properties from untagged cardiac images and corresponding hemodynamic measurements. An example is examined of applying this inverse solution procedure to actual clinical patient data, including standard clinical imaging and interventricular pressure measurement. The results show that the inverse solution procedure can obtain a consistent estimate for the elastic properties of the heart wall.

Citation

Xu, J., Simon, M. A., Wong, T. C., & Brigham, J. C. (2019). A Clinically Applicable Strategy for Estimation of In Vivo Ventricular Wall Elasticity. In CMBE 2019 Proceedings (265-268)

• Presentation Conference Type: Conference Paper (Published)
• Conference Name: 6th International Conference on Computational and Mathematical Biomedical Engineering
• Acceptance Date: Jun 1, 2019
• Online Publication Date: Jun 1, 2019
• Publication Date: 2019-06
• Deposit Date: Jul 1, 2019
• Publicly Available Date: Jul 1, 2019
• Volume: 1
• Pages: 265-268
• Series Title: Proceedings of the 6th International Conference on Computational & Mathematical
• Series ISSN: 2227-3085,2227-9385
• Book Title: CMBE 2019 Proceedings
• Public URL: https://durham-repository.worktribe.com/output/1141910