PglZ from Type I BREX phage defence systems is a metal-dependent nuclease that forms a sub-complex with BrxB
(2025)
Journal Article
Readshaw, J. J., Doyle, L. A., Puiu, M., Kelly, A., Nelson, A., Kaiser, A. J., McGuire, S. F., Peralta Acosta, J., Smith, D. L., Stoddard, B. L., Kaiser, B. K., & Blower, T. R. (2025). PglZ from Type I BREX phage defence systems is a metal-dependent nuclease that forms a sub-complex with BrxB. Nucleic Acids Research, 53(12), Article gkaf540. https://doi.org/10.1093/nar/gkaf540
BREX (Bacteriophage Exclusion) systems, identified through shared identity with Pgl (Phage Growth Limitation) systems, are a widespread, highly diverse group of phage defence systems found throughout bacteria and archaea. The varied BREX Types harbou... Read More about PglZ from Type I BREX phage defence systems is a metal-dependent nuclease that forms a sub-complex with BrxB.