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Plant NETWORKED and VAP27 Proteins Work in Complexes to Regulate Membrane-Based Functions

Duckney, Patrick J.; Wang, Pengwei; Hussey, Patrick J.

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Authors

Pengwei Wang



Abstract

Eukaryotic cells are subdivided into specialised organelle compartments, each with unique physiological environments and functions. Interaction and cross-talk between organelles is inherent to Eukaryotic life, and each organelle is physically interconnected to their surrounding subcellular components including the cytoskeleton and adjacent membrane compartments. In animals and yeast, the mechanisms of organelle interaction have been well characterised and are known to have fundamental importance to life. In contrast, we are only beginning to understand the mechanisms and functions of such interactions in plants. The discovery and ongoing characterisation of the NETWORKED (NET) protein family of plant actin-membrane adaptors has greatly advanced our understanding of the mechanisms of organelle-cytoskeletal interaction. Furthermore, unfolding investigation into the NET proteins has revealed their binding partner, VAMP-ASSOCIATED PROTEIN-27 (VAP27), to be a regulator of organelle tethering and interaction with previously unknown, specialised roles in plants. Research on NET and VAP27 proteins has rapidly increased our knowledge of the mechanisms regulating membrane interaction in plants, their functions in regulating cell structure and organisation, as well as their importance to plant growth, development and stress-response. Here, we discuss the discovery and characterisation of the NET and VAP27 proteins, their regulation of organelle interaction and their functions in plants.

Citation

Duckney, P. J., Wang, P., & Hussey, P. J. (2025). Plant NETWORKED and VAP27 Proteins Work in Complexes to Regulate Membrane-Based Functions. Contact, 8, https://doi.org/10.1177/25152564251342533

Journal Article Type Review
Acceptance Date Apr 29, 2025
Online Publication Date May 27, 2025
Publication Date May 27, 2025
Deposit Date Jun 20, 2025
Publicly Available Date Jun 26, 2025
Journal Contact
Electronic ISSN 2515-2564
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Volume 8
DOI https://doi.org/10.1177/25152564251342533
Public URL https://durham-repository.worktribe.com/output/4109201

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