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The Novel Cytokine Interleukin-41/Meteorin-like Is Reduced in Diffuse Systemic Sclerosis (2024)
Journal Article
Freedman, P., Schock, B., & O’Reilly, S. (2024). The Novel Cytokine Interleukin-41/Meteorin-like Is Reduced in Diffuse Systemic Sclerosis. Cells, 13(14), Article 1205. https://doi.org/10.3390/cells13141205

Systemic sclerosis (SSc) is an autoimmune connective tissue disease with a triad of features that include vascular abnormalities, inflammation and skin and lung fibrosis. At the core of the disease is the activation of myofibroblasts from quiescent f... Read More about The Novel Cytokine Interleukin-41/Meteorin-like Is Reduced in Diffuse Systemic Sclerosis.

Senescence and tissue fibrosis: opportunities for therapeutic targeting. (2024)
Journal Article
O'Reilly, S., Tsou, P.-S., & Varga, J. (online). Senescence and tissue fibrosis: opportunities for therapeutic targeting. Trends in Molecular Medicine, S1471-4914(24)00134-5. https://doi.org/10.1016/j.molmed.2024.05.012

Cellular senescence is a key hallmark of aging. It has now emerged as a key mediator in normal tissue turnover and is associated with a variety of age-related diseases, including organ-specific fibrosis and systemic sclerosis (SSc). This review discu... Read More about Senescence and tissue fibrosis: opportunities for therapeutic targeting..

Emerging therapeutic targets in systemic sclerosis. (2024)
Journal Article
O'Reilly, S. (2024). Emerging therapeutic targets in systemic sclerosis. Journal of Molecular Medicine, 102(4), 465-478. https://doi.org/10.1007/s00109-024-02424-w

Systemic sclerosis is an autoimmune connective tissue disease which is characterised by vascular perturbations, inflammation, and fibrosis. Although huge progress recently into the underlying molecular pathways that are perturbed in the disease, curr... Read More about Emerging therapeutic targets in systemic sclerosis..

S100A4 a classical DAMP as a therapeutic target in fibrosis. (2024)
Journal Article
O'Reilly, S. (2024). S100A4 a classical DAMP as a therapeutic target in fibrosis. Matrix Biology, 127, 1-7. https://doi.org/10.1016/j.matbio.2024.01.002

Fibrosis regardless of aetiology is characterised by persistently activated myofibroblasts that are contractile and secrete excessive amounts of extracellular matrix molecules that leads to loss of organ function. Damage-Associated Molecular Patterns... Read More about S100A4 a classical DAMP as a therapeutic target in fibrosis..