Senescence and tissue fibrosis: opportunities for therapeutic targeting.

O'Reilly, Steven; Tsou, Pei-Suen; Varga, John

Abstract

Cellular senescence is a key hallmark of aging. It has now emerged as a key mediator in normal tissue turnover and is associated with a variety of age-related diseases, including organ-specific fibrosis and systemic sclerosis (SSc). This review discusses the recent evidence of the role of senescence in tissue fibrosis, with an emphasis on SSc, a systemic autoimmune rheumatic disease. We discuss the physiological role of these cells, their role in fibrosis, and that targeting these cells specifically could be a new therapeutic avenue in fibrotic disease. We argue that targeting senescent cells, with senolytics or senomorphs, is a viable therapeutic target in fibrotic diseases which remain largely intractable. [Abstract copyright: Copyright © 2024 Elsevier Ltd. All rights reserved.]

Citation

O'Reilly, S., Tsou, P.-S., & Varga, J. (2024). Senescence and tissue fibrosis: opportunities for therapeutic targeting. Trends in Molecular Medicine, 30(12), 1113-1125. https://doi.org/10.1016/j.molmed.2024.05.012

• Journal Article Type: Article
• Acceptance Date: May 22, 2024
• Online Publication Date: Jun 17, 2024
• Publication Date: 2024-12
• Deposit Date: Jul 24, 2024
• Journal: Trends in molecular medicine
• Print ISSN: 1471-4914
• Electronic ISSN: 1471-499X
• Publisher: Cell Press
• Peer Reviewed: Peer Reviewed
• Volume: 30
• Issue: 12
• Pages: 1113-1125
• DOI: https://doi.org/10.1016/j.molmed.2024.05.012
• Keywords: myofibroblasts, SASP, senescence, systemic sclerosis, fibrosis
• Public URL: https://durham-repository.worktribe.com/output/2520460