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Outputs (10)

Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila (2019)
Journal Article
Schinaman, J. M., Rana, A., Ja, W. W., Clark, R. I., & Walker, D. W. (2019). Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila. Scientific Reports, 9(1), Article 7824. https://doi.org/10.1038/s41598-019-44106-5

The FDA approved drug rapamycin can prolong lifespan in diverse species and delay the onset of age-related disease in mammals. However, a number of fundamental questions remain unanswered regarding the mechanisms by which rapamycin modulates age-rela... Read More about Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila.

Intestinal Snakeskin Limits Microbial Dysbiosis During Aging and Promotes Longevity (2018)
Journal Article
Salazar, A. M., Resnik-Docampo, M., Ulgherait, M., Clark, R. I., Shirazu-Hiza, M., Jones, D. L., & Walker, D. W. (2018). Intestinal Snakeskin Limits Microbial Dysbiosis During Aging and Promotes Longevity. iScience, 9, 229-243. https://doi.org/10.1016/j.isci.2018.10.022

Intestinal barrier dysfunction is an evolutionarily conserved hallmark of aging, which has been linked to microbial dysbiosis, altered expression of occluding junction proteins, and impending mortality. However, the interplay between intestinal junct... Read More about Intestinal Snakeskin Limits Microbial Dysbiosis During Aging and Promotes Longevity.

Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis (2016)
Journal Article
Resnik-Docampo, M., Koehler, C. L., Clark, R. I., Schinaman, J. M., Sauer, V., Wong, D. M., …Jones, D. L. (2016). Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis. Nature Cell Biology, 19(1), 52-59. https://doi.org/10.1038/ncb3454

Ageing results in loss of tissue homeostasis across taxa1. In the intestine of Drosophila melanogaster, ageing is correlated with an increase in intestinal stem cell (ISC) proliferation, a block in terminal differentiation of progenitor cells, activa... Read More about Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis.

Distinct shifts in microbiota composition during Drosophila aging impair intestinal function and drive mortality (2015)
Journal Article
Clark, R., Salazar, A., Yamada, R., Fitz-Gibbon, S., Morselli, M., Alcaraz, J., …Walker, D. (2015). Distinct shifts in microbiota composition during Drosophila aging impair intestinal function and drive mortality. Cell Reports, 12(10), 1656-1667. https://doi.org/10.1016/j.celrep.2015.08.004

Alterations in the composition of the intestinal microbiota have been correlated with aging and measures of frailty in the elderly. However, the relationships between microbial dynamics, age-related changes in intestinal physiology, and organismal he... Read More about Distinct shifts in microbiota composition during Drosophila aging impair intestinal function and drive mortality.

Comparative genomics of the mimicry switch in Papilio dardanus (2014)
Journal Article
Timmermans, M., Baxter, S., Clark, R., Heckel, D., Vogel, H., Collins, S., Papanicolaou, A., Fukova, I., Joron, M., Thompson, M., Jiggins, C., ffrench-Constant, R., & Vogler, A. (2014). Comparative genomics of the mimicry switch in Papilio dardanus. Proceedings of the Royal Society B: Biological Sciences, 281(1787), https://doi.org/10.1098/rspb.2014.0465

The African Mocker Swallowtail, Papilio dardanus, is a textbook example in evolutionary genetics. Classical breeding experiments have shown that wing pattern variation in this polymorphic Batesian mimic is determined by the polyallelic H locus that c... Read More about Comparative genomics of the mimicry switch in Papilio dardanus.

MEF2 is an in vivo immune-metabolic switch (2013)
Journal Article
Clark, R., Tan, S., Pean, C., Roostalu, U., Vivancos, V., Bronda, K., …Dionne, M. (2013). MEF2 is an in vivo immune-metabolic switch. Cell, 155(2), 435-447. https://doi.org/10.1016/j.cell.2013.09.007

Infections disturb metabolic homeostasis in many contexts, but the underlying connections are not completely understood. To address this, we use paired genetic and computational screens in Drosophila to identify transcriptional regulators of immunity... Read More about MEF2 is an in vivo immune-metabolic switch.

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila. (2012)
Journal Article
Rera, M., Clark, R., & Walker, D. (2012). Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila. Proceedings of the National Academy of Sciences, 109(52), 21528-21533. https://doi.org/10.1073/pnas.1215849110

Aging is characterized by a growing risk of disease and death, yet the underlying pathophysiology is poorly understood. Indeed, little is known about how the functional decline of individual organ systems relates to the integrative physiology of agin... Read More about Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila..

Multiple TGF-β superfamily signals modulate the adult Drosophila immune response (2011)
Journal Article
Clark, R., Woodcock, K., Geissmann, F., Trouillet, C., & Dionne, M. (2011). Multiple TGF-β superfamily signals modulate the adult Drosophila immune response. Current Biology, 21(19), 1672-1677. https://doi.org/10.1016/j.cub.2011.08.048

TGF-β superfamily signals play complex roles in regulation of tissue repair and inflammation in mammals [1]. Drosophila melanogaster is a well-established model for the study of innate immune function [2, 3] and wound healing [4–7]. Here, we explore... Read More about Multiple TGF-β superfamily signals modulate the adult Drosophila immune response.