Multiple TGF-β superfamily signals modulate the adult Drosophila immune response

Clark, R.I.; Woodcock, K.J.; Geissmann, F.; Trouillet, C.; Dionne, M.S.

Abstract

TGF-β superfamily signals play complex roles in regulation of tissue repair and inflammation in mammals [1]. Drosophila melanogaster is a well-established model for the study of innate immune function [2, 3] and wound healing [4–7]. Here, we explore the role and regulation of two TGF-β superfamily members, dawdle and decapentaplegic (dpp), in response to wounding and infection in adult Drosophila. We find that both TGF-β signals exhibit complex regulation in response to wounding and infection, each is expressed in a subset of phagocytes, and each inhibits a specific arm of the immune response. dpp is rapidly activated by wounds and represses the production of antimicrobial peptides; flies lacking dpp function display persistent, strong antimicrobial peptide expression after even a small wound. dawdle, in contrast, is activated by Gram-positive bacterial infection but repressed by Gram-negative infection or wounding; its role is to limit infection-induced melanization. Flies lacking dawdle function exhibit melanization even when uninfected. Together, these data imply a model in which the bone morphogenetic protein (BMP) dpp is an important inhibitor of inflammation following sterile injury whereas the activin-like dawdle determines the nature of the induced immune response.

Citation

Clark, R., Woodcock, K., Geissmann, F., Trouillet, C., & Dionne, M. (2011). Multiple TGF-β superfamily signals modulate the adult Drosophila immune response. Current Biology, 21(19), 1672-1677. https://doi.org/10.1016/j.cub.2011.08.048

• Journal Article Type: Article
• Acceptance Date: Aug 19, 2011
• Online Publication Date: Sep 29, 2011
• Publication Date: Oct 11, 2011
• Deposit Date: Aug 13, 2015
• Publicly Available Date: Jun 15, 2018
• Journal: Current Biology
• Print ISSN: 0960-9822
• Electronic ISSN: 1879-0445
• Publisher: Cell Press
• Peer Reviewed: Peer Reviewed
• Volume: 21
• Issue: 19
• Pages: 1672-1677
• DOI: https://doi.org/10.1016/j.cub.2011.08.048
• Public URL: https://durham-repository.worktribe.com/output/1433883