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Directed Mutagenesis for Arginine Substitution of a Phaseolus acutifolius Recombinant Lectin Disrupts Its Cytotoxic Activity (2024)
Journal Article
Martínez-Alarcón, D., Castro-Guillén, J. L., Fitches, E., Gatehouse, J. A., Przyborski, S., Moreno-Celis, U., Blanco-Labra, A., & García-Gasca, T. (2024). Directed Mutagenesis for Arginine Substitution of a Phaseolus acutifolius Recombinant Lectin Disrupts Its Cytotoxic Activity. International Journal of Molecular Sciences, 25(24), Article 13258. https://doi.org/10.3390/ijms252413258

Recently, we reported that a recombinant Tepary bean (Phaseolus acutifolius) lectin (rTBL-1) induces apoptosis in colon cancer cell lines and that cytotoxicity was related to differential recognition of β1-6 branched N-glycans. Sequencing analysis an... Read More about Directed Mutagenesis for Arginine Substitution of a Phaseolus acutifolius Recombinant Lectin Disrupts Its Cytotoxic Activity.

Spider venom neurotoxin based bioinsecticides: A novel bioactive for the control of the Asian citrus psyllid Diaphorina citri (Hemiptera) (2024)
Journal Article
Miranda, M. P., Fitches, E. C., Sukiran, N. A., Eduardo, W. I., Garcia, R. B., Jaciani, F. J., …Peña, L. (2024). Spider venom neurotoxin based bioinsecticides: A novel bioactive for the control of the Asian citrus psyllid Diaphorina citri (Hemiptera). Toxicon: An Interdisciplinary Journal on the Toxins Derived from Animals, Plants and Microorganisms, 239, Article 107616. https://doi.org/10.1016/j.toxicon.2024.107616

The Asian citrus psyllid, Diaphorina citri Kuwayama (Hemiptera: Psyllidae), is a key vector of the phloem-limited bacteria Candidatus Liberibacter asiaticus (CLas) associated with huanglongbing (HLB), the most serious and currently... Read More about Spider venom neurotoxin based bioinsecticides: A novel bioactive for the control of the Asian citrus psyllid Diaphorina citri (Hemiptera).