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SUMO mediated regulation of transcription factors as a mechanism for transducing environmental cues into cellular signaling in plants (2021)
Journal Article
Roy, D., & Sadanandom, A. (2021). SUMO mediated regulation of transcription factors as a mechanism for transducing environmental cues into cellular signaling in plants. Cellular and Molecular Life Sciences, 78(6), 2641-2664. https://doi.org/10.1007/s00018-020-03723-4

Across all species, transcription factors (TFs) are the most frequent targets of SUMOylation. The effect of SUMO conjugation on the functions of transcription factors has been extensively studied in animal systems, with over 200 transcription factors... Read More about SUMO mediated regulation of transcription factors as a mechanism for transducing environmental cues into cellular signaling in plants.

Towards understanding the multifaceted role of SUMOylation in plant growth and development (2020)
Journal Article
Srivastava, M., Sadanandom, A., & Srivastava, A. K. (2020). Towards understanding the multifaceted role of SUMOylation in plant growth and development. Physiologia Plantarum, 171(1), 77-85. https://doi.org/10.1111/ppl.13204

Post‐translational modifications (PTMs) play a critical role in regulating plant growth and development through the modulation of protein functionality and its interaction with its partners. Analysis of the functional implication of PTMs on plant cel... Read More about Towards understanding the multifaceted role of SUMOylation in plant growth and development.

HEARTBREAK Controls Post-translational Modification of INDEHISCENT to Regulate Fruit Morphology in Capsella (2020)
Journal Article
Dong, Y., Majda, M., Šimura, J., Horvath, R., Srivastava, A. K., Łangowski, Ł., Eldridge, T., Stacey, N., Slotte, T., Sadanandom, A., Ljung, K., Smith, R. S., & Østergaard, L. (2020). HEARTBREAK Controls Post-translational Modification of INDEHISCENT to Regulate Fruit Morphology in Capsella. Current Biology, 30(19), 3880-3888.e5. https://doi.org/10.1016/j.cub.2020.07.055

Morphological variation is the basis of natural diversity and adaptation. For example, angiosperms (flowering plants) evolved during the Cretaceous period more than 100 mya and quickly colonized terrestrial habitats [1]. A major reason for their asto... Read More about HEARTBREAK Controls Post-translational Modification of INDEHISCENT to Regulate Fruit Morphology in Capsella.

SUMO Conjugation to BZR1 Enables Brassinosteroid Signaling to Integrate Environmental Cues to Shape Plant Growth (2020)
Journal Article
Srivastava, M., Srivastava, A. K., Orosa-Puente, B., Campanaro, A., Zhang, C., & Sadanandom, A. (2020). SUMO Conjugation to BZR1 Enables Brassinosteroid Signaling to Integrate Environmental Cues to Shape Plant Growth. Current Biology, 30(8), 1423.e3-1423.e3. https://doi.org/10.1016/j.cub.2020.01.089

Brassinosteroids (BRs) play crucial roles in plant development, but little is known of mechanisms that integrate environmental cues into BR signaling. Conjugation to the small ubiquitin-like modifier (SUMO) is emerging as an important mechanism to tr... Read More about SUMO Conjugation to BZR1 Enables Brassinosteroid Signaling to Integrate Environmental Cues to Shape Plant Growth.

Identification of Transgene-Free CRISPR-Edited Plants of Rice, Tomato, and Arabidopsis by Monitoring DsRED Fluorescence in Dry Seeds (2019)
Journal Article
Aliaga-Franco, N., Zhang, C., Presa, S., Srivastava, A. K., Granell, A., Alabadí, D., Sadanandom, A., Blázquez, M. A., & Minguet, E. G. (2019). Identification of Transgene-Free CRISPR-Edited Plants of Rice, Tomato, and Arabidopsis by Monitoring DsRED Fluorescence in Dry Seeds. Frontiers in Plant Science, 10, Article 1150. https://doi.org/10.3389/fpls.2019.01150

Efficient elimination of the editing machinery remains a challenge in plant biotechnology after genome editing to minimize the probability of off-target mutations, but it is also important to deliver end users with edited plants free of foreign DNA.... Read More about Identification of Transgene-Free CRISPR-Edited Plants of Rice, Tomato, and Arabidopsis by Monitoring DsRED Fluorescence in Dry Seeds.

Dealing With Stress: A Review of Plant SUMO Proteases (2019)
Journal Article
Morrell, R., & Sadanandom, A. (2019). Dealing With Stress: A Review of Plant SUMO Proteases. Frontiers in Plant Science, 10, Article 1122. https://doi.org/10.3389/fpls.2019.01122

The SUMO system is a rapid dynamic post-translational mechanism employed by eukaryotic cells to respond to stress. Plant cells experience hyperSUMOylation of substrates in response to stresses such as heat, ethanol, and drought. Many SUMOylated prote... Read More about Dealing With Stress: A Review of Plant SUMO Proteases.

Root branching toward water involves posttranslational modification of transcription factor ARF7 (2018)
Journal Article
Orosa-Puente, B., Leftley, N., von Wangenheim, D., Banda, J., Srivastava, A. K., Hill, K., Truskina, J., Bhosale, R., Morris, E., Srivastava, M., Kümpers, B., Goh, T., Fukaki, H., Vermeer, J. E., Vernoux, T., Dinneny, J. R., French, A. P., Bishopp, A., Sadanandom, A., & Bennett, M. J. (2018). Root branching toward water involves posttranslational modification of transcription factor ARF7. Science, 362(6421), 1407-1410. https://doi.org/10.1126/science.aau3956

Plants adapt to heterogeneous soil conditions by altering their root architecture. For example, roots branch when in contact with water using the hydropatterning response. We report that hydropatterning is dependent on auxin response factor ARF7. Thi... Read More about Root branching toward water involves posttranslational modification of transcription factor ARF7.

SUMO conjugation to the pattern recognition receptor FLS2 triggers intracellular signalling in plant innate immunity (2018)
Journal Article
Orosa, B., Yates, G., Verma, V., Srivastava, A. K., Srivastava, M., Campanaro, A., De Vega, D., Fernandes, A., Zhang, C., Lee, J., Bennett, M. J., & Sadanandom, A. (2018). SUMO conjugation to the pattern recognition receptor FLS2 triggers intracellular signalling in plant innate immunity. Nature Communications, 9(1), Article 5185. https://doi.org/10.1038/s41467-018-07696-8

Detection of conserved microbial patterns by host cell surface pattern recognition receptors (PRRs) activates innate immunity. The FLAGELLIN-SENSITIVE 2 (FLS2) receptor perceives bacterial flagellin and recruits another PRR, BAK1 and the cytoplasmic-... Read More about SUMO conjugation to the pattern recognition receptor FLS2 triggers intracellular signalling in plant innate immunity.

SUMO Suppresses the Activity of the Jasmonic Acid Receptor CORONATINE INSENSITIVE1 (2018)
Journal Article
Srivastava, A. K., Orosa, B., Singh, P., Cummins, I., Walsh, C., Zhang, C., Grant, M., Roberts, M. R., Anand, G. S., Fitches, E., & Sadanandom, A. (2018). SUMO Suppresses the Activity of the Jasmonic Acid Receptor CORONATINE INSENSITIVE1. The Plant Cell, 30(9), 2099-2115. https://doi.org/10.1105/tpc.18.00036

Plants respond rapidly to sudden environmental cues, often responding prior to changes in the hormone levels that coordinate these responses. How this is achieved is not fully understood. The integrative role of the phytohormone jasmonic acid (JA) re... Read More about SUMO Suppresses the Activity of the Jasmonic Acid Receptor CORONATINE INSENSITIVE1.