Outputs (27)

An unexpected chlorination of an organic sunscreen (2025)
Journal Article
Smith, L. G., Di Leva, D., Shaw, L. A., Hughes, E., Kenwright, A. M., Beeby, A., Wilson, M. R., & Mahon, C. S. (online). An unexpected chlorination of an organic sunscreen. Chemical Communications, https://doi.org/10.1039/d5cc01593f

The origin of intense red staining on fabrics contaminated by sunscreen and treated with bleach has been attributed to an unexpected dichlorination of a common UV filter. The structure of the chromophore has been determined by NMR spectroscopy, and t... Read More about An unexpected chlorination of an organic sunscreen.

Designing lenalidomide cocrystals with an extended-release profile for improved pulmonary drug delivery (2025)
Journal Article
Screen, M. A., Tomkinson, G., McCabe, J. F., Askin, S., Mahon, C. S., Wilson, M. R., & Steed, J. W. (2025). Designing lenalidomide cocrystals with an extended-release profile for improved pulmonary drug delivery. New Journal of Chemistry, 49(16), 6535-6543. https://doi.org/10.1039/d5nj00425j

Lenalidomide is a poorly soluble immunomodulatory drug that has been the subject of several cocrystal studies aiming to improve oral bioavailability by enhancing solubility. In contrast, for application in pulmonary fibrosis, reduced solubility may e... Read More about Designing lenalidomide cocrystals with an extended-release profile for improved pulmonary drug delivery.

Surface Modification of Polyesters Using Biosourced Soil-Release Polymers (2025)
Journal Article
Starck, M., Fiandra, E. F., Binks, J., Si, G., Chilton, R., Sivik, M., Thompson, R. L., Li, J., Wilson, M. R., & Mahon, C. S. (2025). Surface Modification of Polyesters Using Biosourced Soil-Release Polymers. JACS Au, 5(2), 666-674. https://doi.org/10.1021/jacsau.4c00908

Soil-release polymers (SRPs) are important components of fabric care formulations, performing important roles in the cleaning of synthetic fabrics. SRPs modify the surface of textiles and render materials resistant to staining, while offering environ... Read More about Surface Modification of Polyesters Using Biosourced Soil-Release Polymers.

A Glycopolymer Sensor Array That Differentiates Lectins and Bacteria (2024)
Journal Article
Leslie, K. G., Jolliffe, K. A., Müllner, M., New, E. J., Turnbull, W. B., Fascione, M. A., Friman, V.-P., & Mahon, C. S. (2024). A Glycopolymer Sensor Array That Differentiates Lectins and Bacteria. Biomacromolecules, 25(11), 7466-7474. https://doi.org/10.1021/acs.biomac.4c01129

Identification of bacterial lectins offers an attractive route to the development of new diagnostics, but the design of specific sensors is complicated by the low selectivity of carbohydrate-lectin interactions. Here we describe a glycopolymer-based... Read More about A Glycopolymer Sensor Array That Differentiates Lectins and Bacteria.

Sugar-Coated: Can Multivalent Glycoconjugates Improve upon Nature’s Design? (2024)
Journal Article
Leslie, K. G., Berry, S. S., Miller, G. J., & Mahon, C. S. (2024). Sugar-Coated: Can Multivalent Glycoconjugates Improve upon Nature’s Design?. Journal of the American Chemical Society, 146(40), 27215-27232. https://doi.org/10.1021/jacs.4c08818

Multivalent interactions between receptors and glycans play an important role in many different biological processes, including pathogen infection, self-recognition, and the immune response. The growth in the number of tools and techniques toward the... Read More about Sugar-Coated: Can Multivalent Glycoconjugates Improve upon Nature’s Design?.

Adaptable Synthesis of Chondroitin Sulfate Disaccharide Subtypes Preprogrammed for Regiospecific O‐Sulfation (2024)
Journal Article
Wootton, H. S., Berry, S. S., Ferguson, E. L., Mahon, C. S., & Miller, G. J. (2024). Adaptable Synthesis of Chondroitin Sulfate Disaccharide Subtypes Preprogrammed for Regiospecific O‐Sulfation. European Journal of Organic Chemistry, 27(40), Article e202400587. https://doi.org/10.1002/ejoc.202400587

A divergent synthetic route to chondroitin sulfate (CS) disaccharide precursors, including rarer subtypes such as CS-D, has been developed. From common intermediates, a series of thioglycoside D-glucosyl donors and 4,6-O-benzylidene protected D-galac... Read More about Adaptable Synthesis of Chondroitin Sulfate Disaccharide Subtypes Preprogrammed for Regiospecific O‐Sulfation.

Designing biodegradable alternatives to commodity polymers (2023)
Journal Article
Fiandra, E. F., Shaw, L., Starck, M., McGurk, C. J., & Mahon, C. S. (2023). Designing biodegradable alternatives to commodity polymers. Chemical Society Reviews, 23(52), 8085-8105. https://doi.org/10.1039/d3cs00556a

The development and widespread adoption of commodity polymers changed societal landscapes on a global scale. Without the everyday materials used in packaging, textiles, construction and medicine, our lives would be unrecognisable. Through decades of... Read More about Designing biodegradable alternatives to commodity polymers.

Electrochemical and thermal detection of allergenic substance lysozyme with molecularly imprinted nanoparticles (2023)
Journal Article
Singla, P., Kaur, S., Jamieson, O., Dann, A., Garg, S., Mahon, C., …Peeters, M. (2023). Electrochemical and thermal detection of allergenic substance lysozyme with molecularly imprinted nanoparticles. Analytical and Bioanalytical Chemistry, 415(18), 4467-4478. https://doi.org/10.1007/s00216-023-04638-2

Lysozyme (LYZ) is a small cationic protein which is widely used for medical treatment and in the food industry to act as an anti-bacterial agent; however, it can trigger allergic reactions. In this study, high-affinity molecularly imprinted nanoparti... Read More about Electrochemical and thermal detection of allergenic substance lysozyme with molecularly imprinted nanoparticles.

A Tale of Two Bioconjugations: pH Controlled Divergent Reactivity of Protein α-oxo-Aldehydes in Competing α-oxo-Mannich and Catalyst-Free Aldol Ligations (2021)
Journal Article
Keenan, T., Spears, R. J., Akkad, S., Mahon, C. S., Hatton, N. E., Walton, J., Noble, A., Yates, N. D., Baumann, C. G., Parkin, A., Signoret, N., & Fascione, M. A. (2021). A Tale of Two Bioconjugations: pH Controlled Divergent Reactivity of Protein α-oxo-Aldehydes in Competing α-oxo-Mannich and Catalyst-Free Aldol Ligations. ACS Chemical Biology, 16(11), 2387-2400. https://doi.org/10.1021/acschembio.1c00531

Site-selective chemical methods for protein bioconjugation have revolutionized the fields of cell and chemical biology through the development of novel protein/enzyme probes bearing fluorescent, spectroscopic, or even toxic cargos. Herein, we report... Read More about A Tale of Two Bioconjugations: pH Controlled Divergent Reactivity of Protein α-oxo-Aldehydes in Competing α-oxo-Mannich and Catalyst-Free Aldol Ligations.

Glycomacromolecules: Addressing challenges in drug delivery and therapeutic development (2021)
Journal Article
Stuart-Walker, W., & Mahon, C. S. (2021). Glycomacromolecules: Addressing challenges in drug delivery and therapeutic development. Advanced Drug Delivery Reviews, 171, 77-93. https://doi.org/10.1016/j.addr.2021.01.018

Carbohydrate-based materials offer exciting opportunities for drug delivery. They present readily available, biocompatible components for the construction of macromolecular systems which can be loaded with cargo, and can enable targeting of a payload... Read More about Glycomacromolecules: Addressing challenges in drug delivery and therapeutic development.