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Outputs (48)

Delay of reinforcement versus rate of reinforcement in Pavlovian conditioning (2019)
Journal Article
Austen, J. M., & Sanderson, D. J. (2019). Delay of reinforcement versus rate of reinforcement in Pavlovian conditioning. Journal of Experimental Psychology: Animal Learning and Cognition, 45(2), 203-221. https://doi.org/10.1037/xan0000199

Conditioned stimulus (CS) duration is a determinant of conditioned responding, with increases in duration leading to reductions in response rates. The CS duration effect has been proposed to reflect sensitivity to the reinforcement rate across cumula... Read More about Delay of reinforcement versus rate of reinforcement in Pavlovian conditioning.

Continual trials spontaneous recognition tasks in mice: reducing animal numbers and improving our understanding of the mechanisms underlying memory (2018)
Journal Article
Chan, M., Eacott, M. J., Sanderson, D. J., Wang, J., Sun, M., & Easton, A. (2018). Continual trials spontaneous recognition tasks in mice: reducing animal numbers and improving our understanding of the mechanisms underlying memory. Frontiers in Behavioral Neuroscience, 12, Article 214. https://doi.org/10.3389/fnbeh.2018.00214

Spontaneous recognition tasks are widely used as a laboratory measure of memory in animals but give rise to high levels of behavioural noise leading to a lack of reliability. Previous work has shown that a modification of the procedure to allow conti... Read More about Continual trials spontaneous recognition tasks in mice: reducing animal numbers and improving our understanding of the mechanisms underlying memory.

Optogenetic induction of the schizophrenia-related endophenotype of ventral hippocampal hyperactivity causes rodent correlates of positive and cognitive symptoms (2018)
Journal Article
Wolff, A. R., Bygrave, A. M., Sanderson, D. J., Boyden, E. S., Bannerman, D. M., Kullmann, D. M., & Dennis Kätzel, D. (2018). Optogenetic induction of the schizophrenia-related endophenotype of ventral hippocampal hyperactivity causes rodent correlates of positive and cognitive symptoms. Scientific Reports, 8, Article 12871. https://doi.org/10.1038/s41598-018-31163-5

Pathological over-activity of the CA1 subfield of the human anterior hippocampus has been identified as a potential predictive marker for transition from a prodromal state to overt schizophrenia. Psychosis, in turn, is associated with elevated activi... Read More about Optogenetic induction of the schizophrenia-related endophenotype of ventral hippocampal hyperactivity causes rodent correlates of positive and cognitive symptoms.

A biphasic reduction in a measure of palatability following sucrose consumption in mice (2017)
Journal Article
Strickland, J. A., Austen, J. M., & Sanderson, D. J. (2018). A biphasic reduction in a measure of palatability following sucrose consumption in mice. Physiology & Behavior, 184, 129-134. https://doi.org/10.1016/j.physbeh.2017.11.019

Consumption of foods results in a transient reduction in hedonic value that influences the extent and nature of feeding behavior. The time course of this effect, however, is poorly specified. In an initial experiment, using an analysis of the microst... Read More about A biphasic reduction in a measure of palatability following sucrose consumption in mice.

GluA1 AMPAR subunit deletion reduces the hedonic response to sucrose but leaves satiety and conditioned responses intact (2017)
Journal Article
Austen, J. M., Sprengel, R., & Sanderson, D. J. (2017). GluA1 AMPAR subunit deletion reduces the hedonic response to sucrose but leaves satiety and conditioned responses intact. Scientific Reports, 7(1), Article 7424. https://doi.org/10.1038/s41598-017-07542-9

The GluA1 subunit of the AMPA receptor has been implicated in schizophrenia. While GluA1 is important for cognition, it is not clear what the role of GluA1 is in hedonic responses that are relevant to the negative symptoms of disorders such as schizo... Read More about GluA1 AMPAR subunit deletion reduces the hedonic response to sucrose but leaves satiety and conditioned responses intact.

Altered balance of excitatory and inhibitory learning in a genetically modified mouse model of glutamatergic dysfunction relevant to schizophrenia (2017)
Journal Article
Sanderson, D. J., Lee, A., Sprengel, R., Seeburg, P. H., Harrison, P. J., & Bannerman, D. M. (2017). Altered balance of excitatory and inhibitory learning in a genetically modified mouse model of glutamatergic dysfunction relevant to schizophrenia. Scientific Reports, 7(1), Article 1765. https://doi.org/10.1038/s41598-017-01925-8

The GluA1 AMPAR subunit (encoded by the Gria1 gene) has been implicated in schizophrenia. Gria1 knockout in mice results in recently experienced stimuli acquiring aberrantly high salience. This suggests that GluA1 may be important for learning that i... Read More about Altered balance of excitatory and inhibitory learning in a genetically modified mouse model of glutamatergic dysfunction relevant to schizophrenia.

The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice (2017)
Journal Article
Boerner, T., Bygrave, A., Chen, J., Fernando, A., Jackson, S., Barkus, C., …Sanderson, D. J. (2017). The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice. European Journal of Neuroscience, 45(7), 912-921. https://doi.org/10.1111/ejn.13539

Group II metabotropic glutamate receptor agonists have been suggested as potential anti-psychotics, at least in part, based on the observation that the agonist LY354740 appeared to rescue the cognitive deficits caused by non-competitive N-methyl-D-as... Read More about The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice.

Memory-dependent effects on palatability in mice (2016)
Journal Article
Austen, J. M., Strickland, J. A., & Sanderson, D. J. (2016). Memory-dependent effects on palatability in mice. Physiology & Behavior, 167, 92-99. https://doi.org/10.1016/j.physbeh.2016.09.001

While palatability depends on the properties of particular foods, it is also determined by prior experience, suggesting that memory affects the hedonic value of a substance. Here, we report two procedures that affect palatability in mice: negative co... Read More about Memory-dependent effects on palatability in mice.

Contexts control negative contrast and restrict the expression of flavor preference conditioning (2016)
Journal Article
Austen, J. M., & Sanderson, D. J. (2016). Contexts control negative contrast and restrict the expression of flavor preference conditioning. Journal of Experimental Psychology: Animal Learning and Cognition, 42, 95-105. https://doi.org/10.1037/xan0000091

Consumption of a high concentration of sucrose can have either a detrimental, negative contrast effect or a facilitatory, preference conditioning effect on subsequent consumption of a low concentration of sucrose, depending on the cues that are prese... Read More about Contexts control negative contrast and restrict the expression of flavor preference conditioning.