Outputs (48)

A bias-free test of human temporal bisection: Evidence against bisection at the arithmetic mean (2024)
Journal Article
Sanderson, D. J. (2024). A bias-free test of human temporal bisection: Evidence against bisection at the arithmetic mean. Cognition, 247, Article 105770. https://doi.org/10.1016/j.cognition.2024.105770

The temporal bisection procedure has been used to assess theories of time perception. A problem with the procedure for measuring the perceived midpoint of two durations is that the spacing of probe durations affects the length of the bisection point.... Read More about A bias-free test of human temporal bisection: Evidence against bisection at the arithmetic mean.

Knockout of NMDARs in CA1 and dentate gyrus fails to impair temporal control of conditioned behaviour in mice (2023)
Journal Article
Strickland, J., Austen, J., Sprengel, R., & Sanderson, D. (2024). Knockout of NMDARs in CA1 and dentate gyrus fails to impair temporal control of conditioned behaviour in mice. Hippocampus, 34(3), 126-140. https://doi.org/10.1002/hipo.23593

The hippocampus has been implicated in temporal learning. Plasticity within the hippocampus requires NMDA receptor-dependent glutamatergic neurotransmission. We tested the prediction that hippocampal NMDA receptors are required for learning about tim... Read More about Knockout of NMDARs in CA1 and dentate gyrus fails to impair temporal control of conditioned behaviour in mice.

Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience (2022)
Journal Article
Panayi, M. C., Boerner, T., Jahans-Price, T., Huber, A., Sprengel, R., Gilmour, G., Sanderson, D. J., Harrison, P. J., Walton, M. E., & Bannerman, D. M. (2022). Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience. Molecular Psychiatry, 28(2023), 579-587. https://doi.org/10.1038/s41380-022-01861-8

Psychosis in disorders like schizophrenia is commonly associated with aberrant salience and elevated striatal dopamine. However, the underlying cause(s) of this hyper-dopaminergic state remain elusive. Various lines of evidence point to glutamatergic... Read More about Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience.

Reinforcement rate and the balance between excitatory and inhibitory learning: insights from deletion of the GluA1 AMPA receptor subunit (2022)
Journal Article
Austen, J. M., Sprengel, R., & Sanderson, D. J. (2022). Reinforcement rate and the balance between excitatory and inhibitory learning: insights from deletion of the GluA1 AMPA receptor subunit. Journal of Experimental Psychology: Animal Learning and Cognition, 48(4), 307-314. https://doi.org/10.1037/xan0000336

Conditioned responding is sensitive to reinforcement rate. This rate-sensitivity is impaired in genetically modified mice that lack the GluA1 subunit of the AMPA receptor. A time-dependent application of the Rescorla–Wagner learning rule can be used... Read More about Reinforcement rate and the balance between excitatory and inhibitory learning: insights from deletion of the GluA1 AMPA receptor subunit.

Dissociating representations of time and number in reinforcement rate learning by GluA1 AMPAR subunit deletion in mice (2021)
Journal Article
Austen, J. M., Pickering, C., Sprengel, R., & Sanderson, D. J. (2021). Dissociating representations of time and number in reinforcement rate learning by GluA1 AMPAR subunit deletion in mice. Psychological Science, 32(2), 204-217. https://doi.org/10.1177/0956797620960392

Theories of learning differ in whether they assume that learning reflects the strength of an association between memories or symbolic encoding of the statistical properties of events. We provide novel evidence for symbolic encoding of informational v... Read More about Dissociating representations of time and number in reinforcement rate learning by GluA1 AMPAR subunit deletion in mice.

Uncertainty and predictiveness modulate attention in human predictive learning (2020)
Journal Article
Chao, C.-M., McGregor, A., & Sanderson, D. J. (2021). Uncertainty and predictiveness modulate attention in human predictive learning. Journal of Experimental Psychology: General, 150(6), 1177-1202. https://doi.org/10.1037/xge0000991

Attention determines which cues receive processing and are learned about. Learning, however, leads to attentional biases. In the study of animal learning, in some circumstances, cues that have been previously predictive of their consequences are subs... Read More about Uncertainty and predictiveness modulate attention in human predictive learning.

The GluA1 AMPAR subunit is necessary for hedonic responding but not hedonic value in female mice (2020)
Journal Article
Strickland, J. A., Austen, J. M., Sprengel, R., & Sanderson, D. J. (2021). The GluA1 AMPAR subunit is necessary for hedonic responding but not hedonic value in female mice. Physiology & Behavior, 228, Article 113206. https://doi.org/10.1016/j.physbeh.2020.113206

The GluA1 subunit of the AMPA receptor has been implicated in anhedonia. Mice that lack GluA1 (Gria1 knockout mice) show reduced lick cluster size, a measure of palatability in feeding behaviour. This deficit may reflect a role for GluA1 in encoding... Read More about The GluA1 AMPAR subunit is necessary for hedonic responding but not hedonic value in female mice.

Cue duration determines response rate but not rate of acquisition of Pavlovian conditioning in mice (2020)
Journal Article
Austen, J. M., & Sanderson, D. J. (2020). Cue duration determines response rate but not rate of acquisition of Pavlovian conditioning in mice. Quarterly Journal of Experimental Psychology, 73(11), 2026-2035. https://doi.org/10.1177/1747021820937696

The duration of a conditioned stimulus (CS) is a key determinant of Pavlovian conditioning. Rate estimation theory (RET) proposes that reinforcement rate is calculated over cumulative exposure to a cue and the reinforcement rate of a cue, relative to... Read More about Cue duration determines response rate but not rate of acquisition of Pavlovian conditioning in mice.

Spontaneous object-location memory based on environmental geometry is impaired by both hippocampal and dorsolateral striatal lesions (2020)
Journal Article
Poulter, S. L., Kosaki, Y., Sanderson, D. J., & McGregor, A. (2020). Spontaneous object-location memory based on environmental geometry is impaired by both hippocampal and dorsolateral striatal lesions. Brain and Neuroscience Advances, 4, https://doi.org/10.1177/2398212820972599

We examined the role of the hippocampus and the dorsolateral striatum in the representation of environmental geometry using a spontaneous object recognition procedure. Rats were placed in a kite-shaped arena and allowed to explore two distinctive obj... Read More about Spontaneous object-location memory based on environmental geometry is impaired by both hippocampal and dorsolateral striatal lesions.

The NMDA receptor antagonist MK-801 fails to impair long-term recognition memory in mice when the state-dependency of memory is controlled (2019)
Journal Article
Chan, M., Austen, J. M., Eacott, M. J., Easton, A., & Sanderson, D. J. (2019). The NMDA receptor antagonist MK-801 fails to impair long-term recognition memory in mice when the state-dependency of memory is controlled. Neurobiology of Learning and Memory, 161, 57-62. https://doi.org/10.1016/j.nlm.2019.03.006

NMDA receptor-dependent synaptic plasticity has been proposed to be important for encoding of memories. Consistent with this hypothesis, the non-competitive NMDA receptor antagonist, MK-801, has been found to impair performance on tests of memory. In... Read More about The NMDA receptor antagonist MK-801 fails to impair long-term recognition memory in mice when the state-dependency of memory is controlled.