Outputs (12)

Dose-Response of Myofibrillar Protein Synthesis To Ingested Whey Protein During Energy Restriction in Overweight Postmenopausal Women: A Randomized, Controlled Trial (2023)
Journal Article
Larsen, M. S., Witard, O. C., Holm, L., Scaife, P., Hansen, R., Smith, K., …Hansen, M. (2023). Dose-Response of Myofibrillar Protein Synthesis To Ingested Whey Protein During Energy Restriction in Overweight Postmenopausal Women: A Randomized, Controlled Trial. The Journal of Nutrition, 153(11), 3173-3184. https://doi.org/10.1016/j.tjnut.2023.08.011

Background Diet-induced weight loss is associated with a decline in lean body mass, as mediated by an impaired response of muscle protein synthesis (MPS). The dose-response of MPS to ingested protein, with or without resistance exercise, is well cha... Read More about Dose-Response of Myofibrillar Protein Synthesis To Ingested Whey Protein During Energy Restriction in Overweight Postmenopausal Women: A Randomized, Controlled Trial.

Human skeletal muscle metabolic responses to 6 days of high‐fat overfeeding are associated with dietary n‐3PUFA content and muscle oxidative capacity (2020)
Journal Article
Wardle, S. L., Macnaughton, L. S., McGlory, C., Witard, O. C., Dick, J. R., Whitfield, P. D., …Galloway, S. D. (2020). Human skeletal muscle metabolic responses to 6 days of high‐fat overfeeding are associated with dietary n‐3PUFA content and muscle oxidative capacity. Physiological Reports, 8(16), Article e14529. https://doi.org/10.14814/phy2.14529

Understanding human physiological responses to high‐fat energy excess (HFEE) may help combat the development of metabolic disease. We aimed to investigate the impact of manipulating the n‐3PUFA content of HFEE diets on whole‐body and skeletal muscle... Read More about Human skeletal muscle metabolic responses to 6 days of high‐fat overfeeding are associated with dietary n‐3PUFA content and muscle oxidative capacity.

Influence of Fish Oil-Derived n-3 Fatty Acid Supplementation on Changes in Body Composition and Muscle Strength During Short-Term Weight Loss in Resistance-Trained Men (2019)
Journal Article
Philpott, J. D., Bootsma, N. J., Rodriguez-Sanchez, N., Hamilton, D. L., MacKinlay, E., Dick, J., …Witard, O. C. (2019). Influence of Fish Oil-Derived n-3 Fatty Acid Supplementation on Changes in Body Composition and Muscle Strength During Short-Term Weight Loss in Resistance-Trained Men. Frontiers in Nutrition, 6, Article 102. https://doi.org/10.3389/fnut.2019.00102

Background: A detrimental consequence of diet-induced weight loss, common in athletes who participate in weight cutting sports, is muscle loss. Dietary omega-3 polyunsaturated fatty acids (n-3PUFA) exhibit a protective effect on the loss of muscle ti... Read More about Influence of Fish Oil-Derived n-3 Fatty Acid Supplementation on Changes in Body Composition and Muscle Strength During Short-Term Weight Loss in Resistance-Trained Men.

Skipping Breakfast Before Exercise Creates a More Negative 24-hour Energy Balance: A Randomized Controlled Trial in Healthy Physically Active Young Men (2019)
Journal Article
Edinburgh, R. M., Hengist, A., Smith, H. A., Travers, R. L., Betts, J. A., Thompson, D., …Gonzalez, J. T. (2019). Skipping Breakfast Before Exercise Creates a More Negative 24-hour Energy Balance: A Randomized Controlled Trial in Healthy Physically Active Young Men. The Journal of Nutrition, 149(8), 1326-1334. https://doi.org/10.1093/jn/nxz018

Background: At rest, omission of breakfast lowers daily energy intake, but also lowers energy expenditure, attenuating any effect on energy balance. The effect of breakfast omission on energy balance when exercise is prescribed is unclear. Objectives... Read More about Skipping Breakfast Before Exercise Creates a More Negative 24-hour Energy Balance: A Randomized Controlled Trial in Healthy Physically Active Young Men.

Preexercise breakfast ingestion versus extended overnight fasting increases postprandial glucose flux after exercise in healthy men (2018)
Journal Article
Edinburgh, R., Hengist, A., Smith, H., Travers, R., Koumanov, F., Betts, J., …Gonzalez, J. (2018). Preexercise breakfast ingestion versus extended overnight fasting increases postprandial glucose flux after exercise in healthy men. AJP - Endocrinology and Metabolism, 315(5), E1062-E1074. https://doi.org/10.1152/ajpendo.00163.2018

The aim of this study was to characterize postprandial glucose flux after exercise in the fed versus overnight fasted state and to investigate the potential underlying mechanisms. In a randomized order, twelve men underwent breakfast-rest [(BR) 3 h s... Read More about Preexercise breakfast ingestion versus extended overnight fasting increases postprandial glucose flux after exercise in healthy men.

Assessing the Role of Muscle Protein Breakdown in Response to Nutrition and Exercise in Humans (2018)
Journal Article
Tipton, K., Hamilton, D., & Gallagher, I. (2018). Assessing the Role of Muscle Protein Breakdown in Response to Nutrition and Exercise in Humans. Sports Medicine, 48(S1), 53-64. https://doi.org/10.1007/s40279-017-0845-5

Muscle protein breakdown (MPB) is an important metabolic component of muscle remodeling, adaptation to training, and increasing muscle mass. Degradation of muscle proteins occurs via the integration of three main systems—autophagy and the calpain and... Read More about Assessing the Role of Muscle Protein Breakdown in Response to Nutrition and Exercise in Humans.

Branched-chain amino acid ingestion stimulates muscle myofibrillar protein synthesis following resistance exercise in humans (2017)
Journal Article
Jackman, S., Witard, O., Philp, A., Wallis, G., Baar, K., & Tipton, K. (2017). Branched-chain amino acid ingestion stimulates muscle myofibrillar protein synthesis following resistance exercise in humans. Frontiers in Physiology, 8, Article 390. https://doi.org/10.3389/fphys.2017.00390

The ingestion of intact protein or essential amino acids (EAA) stimulates mechanistic target of rapamycin complex-1 (mTORC1) signaling and muscle protein synthesis (MPS) following resistance exercise. The purpose of this study was to investigate the... Read More about Branched-chain amino acid ingestion stimulates muscle myofibrillar protein synthesis following resistance exercise in humans.

The response of muscle protein synthesis following whole-body resistance exercise is greater following 40 g than 20 g of ingested whey protein (2016)
Journal Article
Macnaughton, L., Wardle, S., Witard, O., McGlory, C., Hamilton, D., Jeromson, S., …Tipton, K. (2016). The response of muscle protein synthesis following whole-body resistance exercise is greater following 40 g than 20 g of ingested whey protein. Physiological Reports, 4(15), Article e12893. https://doi.org/10.14814/phy2.12893

The currently accepted amount of protein required to achieve maximal stimulation of myofibrillar protein synthesis (MPS) following resistance exercise is 20–25 g. However, the influence of lean body mass (LBM) on the response of MPS to protein ingest... Read More about The response of muscle protein synthesis following whole-body resistance exercise is greater following 40 g than 20 g of ingested whey protein.

Fish oil supplementation suppresses resistance exercise and feeding-induced increases in anabolic signaling without affecting myofibrillar protein synthesis in young men (2016)
Journal Article
Mcglory, C., Wardle, S., Macnaughton, L., Witard, O., Scott, F., Dick, J., …Tipton, K. (2016). Fish oil supplementation suppresses resistance exercise and feeding-induced increases in anabolic signaling without affecting myofibrillar protein synthesis in young men. Physiological Reports, 4(6), Article e12715. https://doi.org/10.14814/phy2.12715

Fish oil (FO) supplementation potentiates muscle protein synthesis (MPS) in response to a hyperaminoacidemic–hyperinsulinemic infusion. Whether FO supplementation potentiates MPS in response to protein ingestion or when protein ingestion is combined... Read More about Fish oil supplementation suppresses resistance exercise and feeding-induced increases in anabolic signaling without affecting myofibrillar protein synthesis in young men.

Protein considerations for optimising skeletal muscle mass in healthy young and older adults (2016)
Journal Article
Witard, O., Wardle, S., Macnaughton, L., Hodgson, A., & Tipton, K. (2016). Protein considerations for optimising skeletal muscle mass in healthy young and older adults. Nutrients, 8(4), Article 181. https://doi.org/10.3390/nu8040181

Skeletal muscle is critical for human health. Protein feeding, alongside resistance exercise, is a potent stimulus for muscle protein synthesis (MPS) and is a key factor that regulates skeletal muscle mass (SMM). The main purpose of this narrative re... Read More about Protein considerations for optimising skeletal muscle mass in healthy young and older adults.